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Uncategorized Published - 27 April, 2022    By - Dr Clemens
Chronic Pain Following Fracture-Related Surgery: Posttraumatic Rather Than Postsurgical Origin Promotes Chronification—A Prospective Observational Study With 1-Year Follow-up

AUTHORS: Aulenkamp, Jana L. MD et al  Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 974-986 BACKGROUND: Chronic posttraumatic/postsurgical pain (CPSP) is common after traumatic or surgical damage. Exposure to both trauma and surgery, with the potential for repeated bone and nerve damage, may increase the risk of CPSP after fracture-related […]

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Uncategorized Published - 27 April, 2022    By - Dr Clemens
Effectiveness of Perioperative Opioid Educational Initiatives

AUTHORS: Zorrilla-Vaca, Andres MD et al Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 940-951 BACKGROUND:  Opioids are the most commonly prescribed analgesics in the United States. Current guidelines have proposed education initiatives to reduce the risk of chronic opioid consumption, yet there is lack of efficacy data on such interventions. […]

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Uncategorized Published - 26 April, 2022    By - Dr Clemens
Antifibrinolytic Drugs for the Prevention of Bleeding in Pediatric Cardiac Surgery on Cardiopulmonary Bypass

AUTHORS: Siemens, Kristina MD et al  Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 987-1001 BACKGROUND:  Bleeding is one of the commonest complications affecting children undergoing cardiac surgery on cardiopulmonary bypass. Antifibrinolytic drugs are part of a multifaceted approach aimed at reducing bleeding, though sufficiently sized pediatric studies are sparse, and […]

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Uncategorized Published - 26 April, 2022    By - Dr Clemens
Control of Postoperative Hypotension Using a Closed-Loop System for Norepinephrine Infusion in Patients After Cardiac Surgery

AUTHORS: Desebbe, Olivier MD et al  Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 964-973 BACKGROUND: Vasopressors are a cornerstone for the management of vasodilatory hypotension. Vasopressor infusions are currently adjusted manually to achieve a predefined arterial pressure target. We have developed a closed-loop vasopressor (CLV) controller to help correct hypotension […]

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Uncategorized Published - 26 April, 2022    By - Dr Clemens
Prevalence and Outcomes of Opioid Use Disorder in Pediatric Surgical Patients

AUTHORS: Alalade, Emmanuel MD et al Anesthesia & Analgesia: April 2022 BACKGROUND: Chronic opioid use among adolescents is a leading preventable public health problem in the United States. Consequently, a sizable proportion of surgical patients in this age group may have a comorbid opioid use disorder (OUD). No previously published study has examined the prevalence of […]

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Uncategorized Published - 26 April, 2022    By - Dr Clemens
Brain-based measures of nociception during general anesthesia with remifentanil

DG Journal Club AUTHORS: Keerthana Deepti Karunakaran et al PLoS Med. 2022 Apr 22; 19(4): e1003965 BACKGROUND Catheter radiofrequency (RF) ablation for cardiac arrhythmias is a painful procedure. Prior work using functional near-infrared spectroscopy (fNIRS) in patients under general anesthesia has indicated that ablation results in activity in pain-related cortical regions, presumably due to inadequate […]

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Uncategorized Published - 26 April, 2022    By - Dr Clemens
Migraine and genetics: Largest study to date may inspire new treatments

Author: James Kingsland MedicalNewsToday Migraine is a condition that causes a pulsating or throbbing headache, usually on one side of the head. The headache often accompanies other symptoms, such as nausea, hypersensitivity to light and sound, and vomiting. A single episode can last several days with severe cases affecting a person’s ability to work or study. […]

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Uncategorized Published - 25 April, 2022    By - Dr Clemens
Intraoperative Inspiratory Oxygen Fraction and Myocardial Injury After Noncardiac Surgery

AUTHORS: Pedersen, Sofie S. MD et al Anesthesia & Analgesia: April 2022 BACKGROUND: Two trials reported that a high inspiratory oxygen fraction (Fio2) does not promote myocardial infarction or death. Observational studies can provide larger statistical strength, but associations can be due to unobserved confounding. Therefore, we evaluated the association between intraoperative Fio2 and cardiovascular complications in […]

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Uncategorized Published - 25 April, 2022    By - Dr Clemens
Liver Fibrosis Marker and Postoperative Mortality in Patients Without Overt Liver Disease

AUTHORS: Zelber-Sagi, Shira PhD et al Anesthesia & Analgesia: April 2022 BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) can progress to advanced fibrosis, which, in the nonsurgical population, is associated with poor hepatic and extrahepatic outcomes. Despite its high prevalence, NAFLD and related liver fibrosis may be overlooked during the preoperative evaluation, and the role of liver […]

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Uncategorized Published - 25 April, 2022    By - Dr Clemens
Combined femoral-obturator-sciatic nerve block has superior postoperative pain score and earlier ambulation as compared to spinal anaesthesia for arthroscopic anterior cruciate ligament reconstruction

DG Journal Club AUTHORS: Tarun Goyal et al Knee Surg Sports Traumatol Arthrosc. 2022 Apr 2 PURPOSE Peripheral nerve blocks can be a suitable alternative to central neuraxial blockage, as the sole anaesthetic agent for better early postoperative outcomes, decreased hospital stay and earlier mobilisation after anterior cruciate ligament reconstruction (ACLR) surgery. The purpose of […]

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