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Uncategorized Published - 21 April, 2022    By - Dr Clemens
Patterns and Persistence of Perioperative Plasma and Cerebrospinal Fluid Neuroinflammatory Protein Biomarkers After Elective Orthopedic Surgery Using SOMAscan

AUTHORS: Dillon, Simon T. PhD et al Anesthesia & Analgesia: April 2022 BACKGROUND: The neuroinflammatory response to surgery can be characterized by peripheral acute plasma protein changes in blood, but corresponding, persisting alterations in cerebrospinal fluid (CSF) proteins remain mostly unknown. Using the SOMAscan assay, we define acute and longer-term proteome changes associated with surgery in […]

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Uncategorized Published - 21 April, 2022    By - Dr Clemens
Mindfulness-Based Therapy Reduces Opioid Misuse, Chronic Pain in Primary Care

DG News An 8-week mindfulness-based therapy — Mindfulness-Oriented Recovery Enhancement (MORE) — decreased opioid use and misuse while reducing chronic pain symptoms, with effects lasting as long as 9 months, according to a study published in JAMA Internal Medicine. This is the first large-scale clinical trial to demonstrate that a psychological intervention can simultaneously reduce opioid […]

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Uncategorized Published - 20 April, 2022    By - Dr Clemens
Rivaroxaban Reduces the Dabigatran Dose Required for Anticoagulation During Simulated Cardiopulmonary Bypass

AUTHORS: Nadtochiy, Sergiy M. PhD et al Anesthesia & Analgesia: April 2022 BACKGROUND: Heparin is the standard anticoagulant for cardiopulmonary bypass (CPB); however, there are problems with its use that make the development of suitable alternatives desirable. Currently, no ideal alternative exists. We have previously reported that the direct thrombin inhibitor dabigatran can prevent coagulation in […]

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Uncategorized Published - 20 April, 2022    By - Dr Clemens
Machine Learning-Based Models Predicting Outpatient Surgery End Time and Recovery Room Discharge at an Ambulatory Surgery Center

AUTHORS: Gabriel, Rodney A. MD, MAS et al Anesthesia & Analgesia: April 2022 BACKGROUND: Days before surgery, add-ons may be scheduled to fill unused surgical block time at an outpatient surgery center. At times, outpatient surgery centers have time limitations for end of block time and discharge from the postanesthesia care unit (PACU). The objective of […]

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Uncategorized Published - 20 April, 2022    By - Dr Clemens
PCI vs. CABG for left main disease: Key takeaways from a new meta-analysis

Author: Michael Walter Cardiovascular Business Percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) are associated with comparable survival rates among left main coronary artery disease (LMCAD) patients after 10 years, according to a new meta-analysis published in the American Journal of Cardiology.[1] However, unplanned revascularizations were significantly more common among patients treated with PCI. […]

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Uncategorized Published - 20 April, 2022    By - Dr Clemens
Effectiveness of prone positioning to reduce the risk of death or respiratory failure in non-critically ill patients hospitalised with COVID-19

DG Alerts Among non-critically ill patients with hypoxaemia who were admitted to hospital with coronavirus disease 2019 (COVID-19), a multifaceted intervention to increase prone positioning did not improve outcomes, according to a study published in The BMJ. However, Michael Fralick, Sinai Health, Toronto, Canada, and colleagues noted that “wide confidence intervals preclude definitively ruling out benefit […]

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Uncategorized Published - 20 April, 2022    By - Dr Clemens
COVID-19 Infection Linked to Higher Risk of Neuropathy

DG News Adding to a growing body of evidence that, for many, problems related to coronavirus disease 2019 (COVID-19) linger longer than the initial infection, researchers have found that some people infected during the pandemic’s early months experienced peripheral neuropathy during and following their bouts with the virus. In a study of more than 1,500 […]

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Uncategorized Published - 19 April, 2022    By - Dr Clemens
Effect of a Rapid Response Team on the Incidence of In-Hospital Mortality

AUTHORS: Factora, Faith MD et al Anesthesia & Analgesia: April 2022 BACKGROUND: Approximately half of the life-limiting events, such as cardiopulmonary arrests or cardiac arrhythmias occurring in hospitals, are considered preventable. These critical events are usually preceded by clinical deterioration. Rapid response teams (RRTs) were introduced to intervene early in the course of clinical deterioration and […]

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Uncategorized Published - 19 April, 2022    By - Dr Clemens
A Prospective, Cohort Study of the Effect of Acute and Chronic Malnutrition on Length of Stay in Children Having Surgery in Rwanda

AUTHORS: Seneza, Celestin MD, MMed et al Anesthesia & Analgesia: April 2022 BACKGROUND: Malnutrition is common in pediatric surgical patients, but there are little data from low-income countries that estimate the association of malnutrition with surgical outcomes. We aimed to determine the prevalence of malnutrition and its association with length of stay (LOS) among pediatric surgical […]

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Uncategorized Published - 19 April, 2022    By - Dr Clemens
Spinal Cord Stimulation Alleviates Neuropathic Pain by Attenuating Microglial Activation via Reducing Colony-Stimulating Factor 1 Levels in the Spinal Cord in a Rat Model of Chronic Constriction Injury

AUTHORS: Sun, Cong MD et al Anesthesia & Analgesia: April 2022 BACKGROUND: Spinal cord stimulation (SCS) is an emerging, minimally invasive procedure used to treat patients with intractable chronic pain conditions. Although several signaling pathways have been proposed to account for SCS-mediated pain relief, the precise mechanisms remain poorly understood. Recent evidence reveals that injured sensory […]

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