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Uncategorized Published - 29 April, 2022    By - Dr Clemens
Novel Opioid Analgesics for the Development of Transdermal Opioid Patches That Possess Morphine-Like Pharmacological Profiles Rather Than Fentanyl

AUTHORS: Komatsu, Akane MD et al Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 1082-1093 BACKGROUND:  Transdermal fentanyl is widely used in the treatment of severe pain because of convenience, safety, and stable blood concentrations. Nevertheless, patients often develop tolerance to fentanyl, necessitating the use of other opioids; transdermal buprenorphine patch […]

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Uncategorized Published - 29 April, 2022    By - Dr Clemens
Intensive Care in Sub-Saharan Africa: A National Review of the Service Status in Ethiopia

AUTHORS: Kifle, Fitsum MSc et al Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 930-937 BACKGROUND:  The burden of critical illness in low-income countries is high and expected to rise. This has implications for wider public health measures including maternal mortality, deaths from communicable diseases, and the global burden of disease […]

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Uncategorized Published - 28 April, 2022    By - Dr Clemens
Sugammadex Versus Neostigmine for Reversal of Residual Neuromuscular Blocks After Surgery

AUTHORS: Ruetzler, Kurt MD, FAHA et al Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 1043-1053 BACKGROUND:  Sugammadex and neostigmine given to reverse residual neuromuscular blockade can cause side effects including bradycardia, anaphylaxis, bronchospasm, and even cardiac arrest. We tested the hypothesis that sugammadex is noninferior to neostigmine on a composite […]

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Uncategorized Published - 28 April, 2022    By - Dr Clemens
Association Between Frailty and Clinical Outcomes and Quality of Life in Older Adults Following Hip Fracture Surgery

AUTHORS: Zhao, Hong MD et al  Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 1035-1042 BACKGROUND:  Hip fracture is a serious event in the older population and is associated with morbidity, mortality, and disability among those who survive. Emerging evidence suggests that frailty is pertinent to the clinical outcomes of older […]

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Uncategorized Published - 28 April, 2022    By - Dr Clemens
Association Between Preoperative Fibrinogen-to-Albumin Ratio and All-Cause Mortality After Off-Pump Coronary Artery Bypass Grafting

AUTHORS: Park, Seoyeong MD et al  Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 1021-1027 BACKGROUND:  The fibrinogen-to-albumin ratio (FAR) is a recently introduced prognostic marker for patients with coronary artery disease. The present study investigated whether the FAR is associated with clinical outcome after off-pump coronary artery bypass grafting (OPCAB). […]

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Uncategorized Published - 28 April, 2022    By - Dr Clemens
Varying Dosages of Subcutaneous Unfractionated Heparin and Activated Partial Thromboplastin Time in Hospitalized Antepartum Patients

AUTHORS: Elmofty, Dalia H. MD Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 1028-1034 BACKGROUND:  Venous thromboembolism (VTE) is a leading cause of maternal morbidity and mortality in the United States. Subcutanous unfractionated heparin (UFH) has been used for decades for VTE prophylaxis and under many obstetric quality of care initiatives, […]

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Uncategorized Published - 28 April, 2022    By - Dr Clemens
Representation of Women as Editors in Anesthesiology Journals

AUTHORS: McMullen, Kaley BS et al Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 956-963   BACKGROUND: Although there has been a considerable increase in the representation of women in medicine, a gender gap still exists with regard to leadership positions. This gender discrepancy has been identified in the field of […]

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Uncategorized Published - 27 April, 2022    By - Dr Clemens
Effectiveness of physiotherapy interventions for back care and the prevention of non-specific low back pain in children and adolescents

DG Journal Club AUTHORS: JosC) Manuel GarcC-a-Moreno et al BMC Musculoskelet Disord. 2022 Apr 2; 23(1): 314 BACKGROUND Non-specific low back pain in children and adolescents has increased in recent years. The purpose of this study was to upgrade the evidence of the most effective preventive physiotherapy interventions to improve back care in children and […]

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Uncategorized Published - 27 April, 2022    By - Dr Clemens
Central Venous-to-Arterial CO2 Difference–Assisted Goal-Directed Hemodynamic Management During Major Surgery

AUTHORS: H N, Lohith Kumar MD et al Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 1010-1020 BACKGROUND:  Different goals have guided goal-directed therapy (GDT). Protocols aiming for central venous-to-arterial carbon dioxide gap (DCO2) <6 mm Hg have improved organ function in septic shock. Evidence for use of DCO2 in the perioperative […]

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Uncategorized Published - 27 April, 2022    By - Dr Clemens
The Association Between Angiotensin II and Renin Kinetics in Patients After Cardiac Surgery

AUTHORS: Meersch, Melanie MD et al Anesthesia & Analgesia: May 2022 – Volume 134 – Issue 5 – p 1002-1009 BACKGROUND:  Hyperreninemia after cardiac surgery is associated with cardiovascular instability. Angiotensin II (AT-II) could potentially attenuate hyperreninemia while maintaining target blood pressure. This study assesses the association between AT-II usage and renin levels in cardiac surgery […]

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