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ASA Monitor October 2023, Vol. 87, 12–13. A new study funded by the National Heart, Blood, and Lung Institute (NHLBI) provides strong evidence for omega-3 fatty acids’ power to maintain lung health. Researchers interested in nutritional interventions that could prevent lung disease have long suspected that omega-3s could aid lung disease prevention due to their anti-inflammatory […]
Read MoreAuthors: Mark A. Shulman, Ph.D. et al Anesthesiology October 2023, Vol. 139, 420–431. Background Older patients are vulnerable to developing new or worsening disability after surgery. Despite this, patient or surgical characteristics predisposing to postoperative disability are poorly defined. The aim of the study was to develop and validate a model, subsequently transformed to point-score form, […]
Read MoreAuthors: Haobo Ma, MD, MSc et al Anesthesiology September 2023. Background The treatment of intraoperative hypotension with phenylephrine may impair cerebral perfusion through vasoconstriction, which has been linked to postoperative delirium. We hypothesized that intraoperative administration of phenylephrine, compared to ephedrine, is associated with higher odds of postoperative delirium. Methods 103,094 hospitalized adults undergoing general […]
Read MoreAuthors: Pavel S. Roshanov et al Anesthesiology September 2023. Background In prior analyses, myocardial injury after noncardiac surgery, major bleeding, and sepsis were independently associated with most deaths in the 30 days after noncardiac surgery, but most of these deaths occurred during the index hospitalization for surgery. We set out to describe outcomes after discharge […]
Read MoreAuthors: Jacqueline M. Leung, M.D., M.P.H. et al Anesthesiology October 2023, Vol. 139, 432–443. Background The pathophysiology of delirium is incompletely understood, including what molecular pathways are involved in brain vulnerability to delirium. This study examined whether preoperative plasma neurodegeneration markers were elevated in patients who subsequently developed postoperative delirium through a retrospective case-control study. Methods […]
Read MoreAuthors: Edita Navratilova, Ph.D. et al Anesthesiology September 2023. Background The efficiency of descending pain modulation, commonly assessed with the conditioned pain modulation (CPM) procedure, is diminished in patients with chronic pain. We hypothesized that the efficiency of pain modulation is controlled by cortical opioid circuits. Methods We evaluated the effects of mu opioid receptor […]
Read MoreAuthor: Wael Saasouh, MD IARS Newsletter Issue 4 Intraoperative hypotension has been shown to negatively influence patient outcomes based on large trials from major academic centers. During the session, “A Pragmatic Discussion on Intraoperative Hypotension” on Saturday, April 15 at the IARS 2023 Annual Meeting, experts on this topic shared the results of similar work […]
Read MoreAUTHORS: Barsky, Daniel MD et al Anesthesia & Analgesia 136(5):p 934-940, May 2023. BACKGROUND: Hemorrhage is the leading cause of preventable death in trauma patients, and establishment of intravenous (IV) access is essential for volume resuscitation, a key component in the treatment of hemorrhagic shock. IV access among patients in shock is generally considered more challenging, […]
Read MoreAUTHORS: Martinez, Thibault MD et al Anesthesia & Analgesia 136(5):p 842-851, May 2023. BACKGROUND: Traumatic rhabdomyolysis (RM) is common and contributes to the development of medical complications, of which acute renal failure is the best described. Some authors have described an association between elevated aminotransferases and RM, suggesting the possibility of associated liver damage. Our study […]
Read MoreAUTHORS: Muldowney, Maeve MB, BCh, BAO et al Anesthesia & Analgesia 136(5):p 927-933, May 2023. BACKGROUND: Uncontrolled bleeding is a leading cause of death in trauma. In the last 40 years, ultramassive transfusion (UMT; ≥20 units of red blood cells [RBCs]/24 hours) for trauma has been associated with 50% to 80% mortality; the question remains as […]
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