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Uncategorized Published - 11 October, 2023    By - Dr Clemens
Brainstem Modulation of Nociception by Periaqueductal Gray Neurons Expressing the μ-Opioid Receptor in Mice

Authors: Eileen Nguyen, M.D., Ph.D. et al  Anesthesiology October 2023, Vol. 139, 462–475. Background Pharmacologic manipulations directed at the periaqueductal gray have demonstrated the importance of the μ-opioid receptor in modulating reflexive responses to nociception. The authors hypothesized that a supraspinal pathway centered on neurons in the periaqueductal gray containing the μ-opioid receptor could modulate nociceptive […]

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Uncategorized Published - 11 October, 2023    By - Dr Clemens
Achieving a Successful Patient Safety Program with Implementation of a Harm Reduction Strategy

Author: Jonathan B. Cohen, MD, MS Anesthesia Patient Safety Foundation Oct 2023 In March of this year, the U.S. Food and Drug Administration (FDA) approved naloxone hydrochloride nasal spray for over-the-counter, nonprescription use. This move was consistent with longstanding recommendations by the American Society of Anesthesiologists (ASA) and testimony given before several of its committees […]

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Uncategorized Published - 10 October, 2023    By - Dr Clemens
Consensus Recommendations for the Safe Conduct of Nonoperating Room Anesthesia: A Meeting Report From the 2022 Stoelting Conference of the Anesthesia Patient Safety Foundation

Authors: John Beard, MD et al Anesthesia Patient Safety Foundation Oct 2023 Nonoperating room anesthesia (NORA) cases are projected to exceed 50% of total anesthesia cases in the near future.1 Although one large-scale study failed to show a difference in mortality between NORA and operating room (OR) settings,2 multiple analyses of data from the American Society of […]

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Uncategorized Published - 10 October, 2023    By - Dr Clemens
Clinician Safety in NORA

Authors: Candace Chang, MD, MPH et  al Anesthesia Patient Safety Foundation Oct 2023 INTRODUCTION While patient safety is an established field of study, little attention has been directed to clinician safety. According to the Occupational Health Safety Network, 1 in 5 nonfatal occupational injuries occurs in the health care and social assistance industry, and health […]

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Uncategorized Published - 10 October, 2023    By - Dr Clemens
Dabigatran in Rabbit Cardiopulmonary Bypass: Comment

Authors: Gabor Erdoes, M.D., Ph.D. et al  Anesthesiology September 2023. To the Editor: Nadtochiy et al.  report using intravenous dabigatran, a direct thrombin inhibitor (DTI), for anticoagulation in an animal model of simulated cardiopulmonary bypass (CPB).  Activated clotting time, thromboelastometric reaction time, and fibrin deposition in sections of the arterial line filters were analyzed to compare anticoagulation with […]

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Uncategorized Published - 10 October, 2023    By - Dr Clemens
Dabigatran in Rabbit Cardiopulmonary Bypass: Reply

Authors: Michael P. Eaton, M.D., F.A.S.A. et al  Anesthesiology September 2023. In Reply: The authors thank Drs. Erdoes, Koster, and Levy for their very cogent and detailed analysis of our study.  We agree with many of the points they made, specifically the very limited effect dabigatran has on coagulation due to its specificity for thrombin. Most would […]

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Uncategorized Published - 10 October, 2023    By - Dr Clemens
29 physician specialties ranked by 2022 burnout rates

Author: Erica Carbajal Becker’s Hospital Review Last year, 53 percent of physicians reported burnout. Among them, emergency medicine specialists had the highest rate at 65 percent, according to Medscape’s latest report on physician burnout and depression. Across the board, physician burnout has jumped 11 percentage points from 2018, when 42 percent of physicians said they were burned out. The […]

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Uncategorized Published - 9 October, 2023    By - Dr Clemens
Are Serious Anesthesia Risks of Semaglutide and Other GLP-1 Agonists Under-Recognized? Case Reports of Retained Solid Gastric Contents in Patients Undergoing Anesthesia

Authors: William Brian Beam, MD; Lindsay R. Hunter Guevara, MD Anesthesia Patient Safety Foundation Oct 2023 SUMMARY: GLP-1 receptor agonists are an increasingly popular class of medications for weight loss and diabetes management. An important mechanism for these medications is direct gastric stimulation of GLP-1 receptors leading to delayed gastric emptying and potential for retained gastric […]

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Uncategorized Published - 9 October, 2023    By - Dr Clemens
Remimazolam: Patient Safety Considerations of a Novel, Practice-Changing Drug in Perioperative Medicine

Authors: Arnoley S. Abcejo, MD; Miguel T. Teixeira, MD Anesthesia Patient Safety Foundation Oct 2023 INTRODUCTION Remimazolam besylate (ByFavo™ in the USA and in South Korea, Anerem® in Japan, Aptimyda™ in EU, and Ruima® in China) is an intravenous, short-acting, and ultrafast onset benzodiazepine (nonanalgesic) with potent sedative-hypnotic, anxiolytic, anticonvulsant, and muscle relaxant properties. As […]

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Uncategorized Published - 9 October, 2023    By - Dr Clemens
Difficult Airway Management in Neonates: Comment

Author: Takashi Asai, M.D., Ph.D. Anesthesiology September 2023. To the Editor: I read with interest the article by Thomas et al. on fiberoptic tracheal intubation via a laryngeal mask airway (LMA) Unique (Laryngeal Mask Company Limited, USA) in neonates. They state that, to perform this, it is necessary to use a second tracheal tube as a “pusher” (not […]

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