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Uncategorized Published - 16 October, 2023    By - Dr Clemens
Opioid analgesia for acute low back pain and neck pain (the OPAL trial)

Authors: Caitlin M P Jones et al Lancet. 2023 Aug 19;402(10402):612 Background: Opioid analgesics are commonly used for acute low back pain and neck pain, but supporting efficacy data are scarce. We aimed to investigate the efficacy and safety of a judicious short course of an opioid analgesic for acute low back pain and neck pain. […]

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Uncategorized Published - 16 October, 2023    By - Dr Clemens
Effectiveness of Lumbar Cerebrospinal Fluid Drain Among Patients With Aneurysmal Subarachnoid Hemorrhage

Authors: Stefan Wolf et al JAMA Neurol 2023 Aug 1;80(8):833-842. Importance: After aneurysmal subarachnoid hemorrhage, the use of lumbar drains has been suggested to decrease the incidence of delayed cerebral ischemia and improve long-term outcome. Objective: To determine the effectiveness of early lumbar cerebrospinal fluid drainage added to standard of care in patients after aneurysmal subarachnoid hemorrhage. […]

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Uncategorized Published - 16 October, 2023    By - Dr Clemens
Association of Genetic Variants with Postsurgical Pain

Authors: Stephan G. Frangakis, M.D., Ph.D. et al  Anesthesiology September 2023. Background Postsurgical pain is a key component of surgical recovery. However, the genetic drivers of postsurgical pain remain unclear. A broad review and meta-analyses of variants of interest will help investigators understand the potential effects of genetic variation. Methods This article is a systematic […]

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Uncategorized Published - 16 October, 2023    By - Dr Clemens
Evaluation of malignant hyperthermia features in patients with pathogenic or likely pathogenic RYR1 variants disclosedthrough a population genomic screening program

Authors: Kristen D. Yu, M.S. et al  Anesthesiology October 2023. Background Malignant hyperthermia (MH) susceptibility is a heritable musculoskeletal disorder that can present as a potentially fatal hypermetabolic response to triggering anesthesia agents. Genomic screening for variants in MH-associated genes RYR1 and CACNA1S provides an opportunity to prevent morbidity and mortality. There are limited outcomes data from disclosing variants […]

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Uncategorized Published - 13 October, 2023    By - Dr Clemens
Recurrent Intraoperative Anesthesia Machine Malfunctions

Authors: David W. Corpman, MD; Linda L. Liu, MD Anesthesia Patient Safety Foundation Oct 2023 Intraoperative equipment failures are increasingly rare events, but may cause serious harm based on an analysis of the American Society of Anesthesiologists (ASA) Closed Claims database.1 Pre-anesthesia checkout procedures strive to make these events preventable, but certain failures cannot be prevented […]

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Uncategorized Published - 13 October, 2023    By - Dr Clemens
Quiz: SCS for Painful Diabetic Neuropathy

Authors: Jake Israel MD, Jeff Gudin MD. Pract Pain Manage. 2023 July/August 23(4). Test your clinical knowledge on the utility of spinal cord stimulation for treating diabetic neuropathy. Diabetic Neuropathy and Spinal Cord Stimulation: A Brief Background Diabetes is the fourth most common disease worldwide, affecting 5.9% of the world’s population.1 A common complication of the […]

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Uncategorized Published - 13 October, 2023    By - Dr Clemens
Aura of Hope for Migraine Patients: Understanding the Latest Cluster of Treatment Options

Authors: Dibash Kumar Das, PhD; Steven L. Shafer, MD, FASA ASA Monitor October 2023, Vol. 87, 1–4. Migraine is a highly prevalent and debilitating condition affecting approximately 10%-15% of the population (Rev Neurol Aug 2023; Lancet 2012;380:2163-96). A migraine is a severe headache lasting up to 72 hours, accompanied by symptoms including nausea, vomiting, and hypersensitivity to light and sound. […]

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Uncategorized Published - 13 October, 2023    By - Dr Clemens
Monitoring of argatroban in critically ill patients: a prospective study comparing aPTT, point-of-care viscoelastic testing with ecarin clotting time and dTT to mass spectrometry

Authors: Lars Heubner, MD et al  Anesthesiology October 2023. Background The direct thrombin inhibitor argatroban is indicated for the treatment of heparin-induced thrombocytopenia II, but it is also used off-label to treat critically ill patients presenting with heparin resistance, severe antithrombin deficiency or hypercoagulability. Direct drug monitoring is not routinely available and argatroban dosing is […]

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Uncategorized Published - 13 October, 2023    By - Dr Clemens
Mindfulness-Based Group Therapy for Geriatric Chronic Pain Management

Author: Kathleen Doheny Practical Pain Management Volume 23 Issue 4 Eight weekly sessions, each 2.5 hours, helped older adults develop a “friendlier” relationship with chronic pain. Mindfulness meditation has been recommended as a nonpharmacological approach to managing chronic pain, but there has been a lack of evidence in older adults. A University of Michigan study […]

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Uncategorized Published - 12 October, 2023    By - Dr Clemens
Analgesic Effectiveness of Motor-sparing Nerve Blocks for Total Knee Arthroplasty

Authors: Nasir Hussain, M.D., M.Sc. et al  Anesthesiology October 2023, Vol. 139, 444–461. Background The analgesic effectiveness of contemporary motor-sparing nerve blocks used in combination for analgesia in total knee arthroplasty is unclear. This network meta-analysis was conducted to evaluate the analgesic effectiveness of adding single-injection or continuous adductor canal block (ACB) with or without infiltration […]

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