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Uncategorized Published - 22 November, 2023    By - Dr Clemens
Sleep Fragmentation, Electroencephalographic Slowing, and Circadian Disarray in a Mouse Model for Intensive Care Unit Delirium

AUTHORS: Dulko, Elzbieta MS et al  Anesthesia & Analgesia 137(1):p 209-220, July 2023. BACKGROUND: We aimed to further validate our previously published animal model for delirium by testing the hypothesis that in aged mice, Anesthesia, Surgery and simulated ICU conditions (ASI) induce sleep fragmentation, electroencephalographic (EEG) slowing, and circadian disarray consistent with intensive care unit (ICU) […]

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Uncategorized Published - 22 November, 2023    By - Dr Clemens
Outpatient Treatment With Gabapentin in Women With Severe Acute Pain After Cesarean Delivery Is Ineffective

AUTHORS: Fowler, Cedar MD, PhD et al  Anesthesia & Analgesia 136(6):p 1122-1132, June 2023. BACKGROUND: Most of the 1.1 million women who deliver by cesarean in the United States each year have an uncomplicated recovery. However, severe pain resistant to standard multimodal therapy within the first days after surgery is associated with an increased risk for […]

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Uncategorized Published - 21 November, 2023    By - Dr Clemens
Maternal Morbidity According to Mode of Delivery Among Pregnant Patients With Pulmonary Hypertension

AUTHORS: Meng, Marie-Louise MD et al Anesthesia & Analgesia May 16, 2023. BACKGROUND: Patients with pulmonary hypertension have a high risk of maternal morbidity and mortality. It is unknown if a trial of labor carries a lower risk of morbidity in these patients compared to a planned cesarean delivery. The objective of this study was […]

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Uncategorized Published - 21 November, 2023    By - Dr Clemens
Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications

AUTHORS: Haller G et al European Journal of Anaesthesiology 34(8):p 492-507, August 2017.  BACKGROUND  Limited information exists about the epidemiology and outcome of surgical patients at increased risk of postoperative pulmonary complications (PPCs), and how intraoperative ventilation was managed in these patients. OBJECTIVES To determine the incidence of surgical patients at increased risk of PPCs, and […]

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Uncategorized Published - 21 November, 2023    By - Dr Clemens
Dexmedetomidine Pretreatment Protects Against Myocardial Ischemia/Reperfusion Injury by Activating STAT3 Signaling

AUTHORS: Chen, Zhao-Rong MM et al  Anesthesia & Analgesia 137(2):p 426-439, August 2023. BACKGROUND: Myocardial infarction is a common perioperative complication, and blood flow restoration causes ischemia/reperfusion injury (IRI). Dexmedetomidine (DEX) pretreatment can protect against cardiac IRI, but the mechanism is still insufficiently understood. METHODS: In vivo, myocardial ischemia/reperfusion (30 minutes/120 minutes) was induced via ligation […]

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