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Uncategorized Published - 27 November, 2023    By - Dr Clemens
Alfaxalone Alleviates Neurotoxicity and Cognitive Impairment Induced by Isoflurane Anesthesia in Offspring Rats

AUTHORS: Zhao, Xingkai MS et al  Anesthesia & Analgesia 136(6):p 1206-1216, June 2023. BACKGROUND: The anesthetic isoflurane can cause neurotoxicity in fetuses and offspring of rats, affecting their neurodevelopment. However, the underlying mechanisms and therapeutic targets of isoflurane-induced neurotoxicity remain to be identified. Alfaxalone (ALF) is a steroid anesthetic. Steroids have been reported to have neuroprotective […]

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Uncategorized Published - 24 November, 2023    By - Dr Clemens
Anesthetic Management and Deep Sedation After Emergence From General Anesthesia

AUTHORS: Deljou, Atousa MD et al  Anesthesia & Analgesia 136(6):p 1154-1163, June 2023. BACKGROUND: Residual deep sedation during anesthesia recovery may predict postoperative complications. We examined the incidence and risk factors for deep sedation after general anesthesia. METHODS: We retrospectively reviewed health records of adults who underwent procedures with general anesthesia and were admitted to the […]

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Uncategorized Published - 24 November, 2023    By - Dr Clemens
Postoperative Outcomes in Elderly Patients Undergoing Cardiac Surgery With Preoperative Cognitive Impairment

AUTHORS: Au, Emily BSc et al  Anesthesia & Analgesia 136(6):p 1016-1028, June 2023. BACKGROUND: Older patients with preoperative cognitive impairment are at risk for increased postoperative complications after noncardiac surgery. This systematic review and meta-analysis aimed to determine the association between preoperative cognitive impairment and dementia and postoperative outcomes in older surgical patients after cardiac surgery. […]

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Uncategorized Published - 24 November, 2023    By - Dr Clemens
Transnasal Humidified Rapid Insufflation Ventilatory Exchange Augments Oxygenation in Children With Juvenile Onset Recurrent Respiratory Papillomatosis During Surgery

AUTHORS: Lei, Guiyu MD et al  Anesthesia & Analgesia 137(3):p 578-586, September 2023. BACKGROUND: Evidence is lacking regarding the efficacy of transnasal humidified rapid insufflation ventilatory exchange (THRIVE) in tubeless anesthesia, especially in pediatric patients. This study aimed to evaluate the use of THRIVE for juvenile onset recurrent respiratory papillomatosis (JORRP) patients. METHODS: Twenty-eight children aged […]

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Uncategorized Published - 24 November, 2023    By - Dr Clemens
Examining Subjective Psychological Experiences of Postoperative Delirium in Older Cardiac Surgery Patients

AUTHORS: Cohen, Caitlin L. BPsych (Hons) et al  Anesthesia & Analgesia 136(6):p 1174-1181, June 2023. BACKGROUND: Postoperative delirium (POD) is an acute syndrome including inattention and impaired cognition that affects approximately 42% of older cardiac surgical patients. POD is linked to adverse outcomes including morbidity, mortality, and further cognitive decline. Less is known about the subjective […]

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