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Uncategorized Published - 24 May, 2024    By - Dr Clemens
Reversal of Propofol-induced Depression of the Hypoxic Ventilatory Response by BK-channel Blocker ENA-001

Authors: Simone C. Jansen, M.D. et al  Anesthesiology June 2024, Vol. 140, 1076–1087. Background The use of anesthetics may result in depression of the hypoxic ventilatory response. Since there are no receptor-specific antagonists for most anesthetics, there is the need for agnostic respiratory stimulants that increase respiratory drive irrespective of its cause. The authors tested whether […]

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Uncategorized Published - 24 May, 2024    By - Dr Clemens
Progressing What’s Possible in Regional Anesthesia and Pain Medicine

Author: David A. Provenzano, MD ASA Monitor January 2024, Vol. 88, e4–e5. With a mission to advance the science and practice of regional anesthesia and pain medicine to improve patient outcomes, the American Society of Regional Anesthesia and Pain Medicine (ASRA Pain Medicine) is always looking at innovative, new ways to progress what’s possible. From new […]

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Uncategorized Published - 23 May, 2024    By - Dr Clemens
Does Propofol Improve Polyp Detection during Colonoscopy?

Authors: Douglas A. Colquhoun, M.B.Ch.B., M.Sc., M.P.H. et al  Anesthesiology June 2024, Vol. 140, 1062–1064. “Despite these limitations, this study still calls attention to the importance of preserving access to routine propofol use in patients undergoing screening and surveillance colonoscopy.” In this month’s issue of Anesthesiology, Quaye et al. report findings of their investigation into differences […]

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Uncategorized Published - 23 May, 2024    By - Dr Clemens
Antithrombin Deficiency during Venoarterial Extracorporeal Membrane Oxygenation: Extremely Common, but Does It Matter?

Authors: Michael Mazzeffi, M.D., M.P.H., F.A.H.A. et al  Anesthesiology June 2024, Vol. 140, 1065–1067. “Management strategies for anticoagulating adult ECMO patients and optimal management continue to be a work in progress.” In this issue of Anesthesiology, Mansour et al. explore the significance of antithrombin deficiency, defined by a time-weighted average antithrombin activity less than 70%, in adults […]

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Uncategorized Published - 23 May, 2024    By - Dr Clemens
Reversal for Respiratory Depression: Let’s Take a Breath!

Author: Thomas K. Henthorn, M.D. Anesthesiology June 2024, Vol. 140, 1059–1061. “Jansen et al. provide evidence that a new BK-channel blocker (i.e., ENA-001) […] may reverse the respiratory depressant effects of propofol, which may add to the utility of arousal-promoting agents and promises its own additional utility of ameliorating propofol’s respiratory depressant effects while permitting sedation.” Respiratory depression […]

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