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Uncategorized Published - 29 May, 2024    By - Dr Clemens
Combined Dexamethasone and Dexmedetomidine as Adjuncts to Popliteal and Saphenous Nerve Blocks in Patients Undergoing Surgery of the Foot or Ankle

Authors: Mathias Maagaard, M.D. et al  Anesthesiology June 2024, Vol. 140, 1165–1175. Background Both dexamethasone and dexmedetomidine increase the duration of analgesia of peripheral nerve blocks. The authors hypothesized that combined intravenous dexamethasone and intravenous dexmedetomidine would result in a greater duration of analgesia when compared with intravenous dexamethasone alone and placebo. Methods The authors randomly […]

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Uncategorized Published - 28 May, 2024    By - Dr Clemens
Antithrombin Levels and Heparin Responsiveness during Venoarterial Extracorporeal Membrane Oxygenation

Authors: Alexandre Mansour, M.D., Ph.D. et al  Anesthesiology June 2024, Vol. 140, 1153–1164. Background Unfractionated heparin, administered during venoarterial extracorporeal membrane oxygenation to prevent thromboembolic events, largely depends on plasma antithrombin for its antithrombotic effects. Decreased heparin responsiveness seems frequent on extracorporeal membrane oxygenation; however, its association with acquired antithrombin deficiency is poorly understood. The objective […]

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Uncategorized Published - 28 May, 2024    By - Dr Clemens
Dexmedetomidine Inhibits Paraventricular Corticotropin-releasing Hormone Neurons that Attenuate Acute Stress-induced Anxiety-like Behavior in Mice

Authors: Gaolin Qiu, M.D. et al  Anesthesiology June 2024, Vol. 140, 1134–1152. Background Dexmedetomidine has repeatedly shown to improve anxiety, but the precise neural mechanisms underlying this effect remain incompletely understood. This study aims to explore the role of corticotropin-releasing hormone–producing hypothalamic paraventricular nucleus (CRHPVN) neurons in mediating the anxiolytic effects of dexmedetomidine. Methods A social […]

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Uncategorized Published - 28 May, 2024    By - Dr Clemens
Association between Colonoscopy Sedation Type and Polyp Detection

Authors: Aurora N. Quaye, M.D. et al  Anesthesiology June 2024, Vol. 140, 1088–1097. Background Colorectal cancer is a leading cause of cancer-related death. Adenomas and serrated polyps are precursors of colorectal cancer, with serrated polyps being more difficult to detect during colonoscopy. The relationship between propofol use and polyp detection remains unclear. The authors investigated the […]

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Uncategorized Published - 28 May, 2024    By - Dr Clemens
Tethered Spinal Cord Syndrome Discovered during Ultrasound-guided Caudal Block

Authors: Ramón Eizaga Rebollar, M.D. et al  Anesthesiology June 2024, Vol. 140, 1203–1204. Figure 1, B and C correspond to a healthy 2-yr-old boy who underwent hypospadias repair during general anesthesia combined with ultrasound-guided continuous caudal block. Mid-sagittal plane lumbar ultrasound (Sonosite SII, FUJIFILM Sonosite, Inc., USA) showed the dural sac end at S4 vertebral level, significantly lower for […]

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