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Uncategorized Published - 28 May, 2024    By - Dr Clemens
μ-Opioid Receptor Activation at the Dorsal Reticular Nucleus Shifts Diffuse Noxious Inhibitory Controls to Hyperalgesia in Chronic Joint Pain in Male Rats

Authors: Raquel Pereira-Silva, Ph.D. et al  Anesthesiology June 2024, Vol. 140, 1176–1191. Background The dorsal reticular nucleus is a pain facilitatory area involved in diffuse noxious inhibitory control (DNIC) through opioidergic mechanisms that are poorly understood. The hypothesis was that signaling of μ-opioid receptors is altered in this area with prolonged chronic inflammatory pain and that […]

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Uncategorized Published - 27 May, 2024    By - Dr Clemens
Happy Memorial Day

Honoring the Heroes: A Reflection on Memorial Day I want to thank our readers and wish them a fun and safe Memorial Day. Please remember that today is a day of reflection, remembrance, and gratitude for those who laid down their lives in service to the nation. Memorial Day serves as a powerful reminder of […]

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Uncategorized Published - 24 May, 2024    By - Dr Clemens
Long-term Survival after Volatile or Propofol General Anesthesia for Bladder Cancer Surgery

Authors: Mats Enlund, M.D., Ph.D. et al  Anesthesiology June 2024, Vol. 140, 1126–1133. Background Prospective interventional trials and retrospective observational analyses provide conflicting evidence regarding the relationship between propofol versus inhaled volatile general anesthesia and long-term survival after cancer surgery. Specifically, bladder cancer surgery lacks prospective clinical trial evidence. Methods Data on bladder cancer surgery performed under general […]

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Uncategorized Published - 24 May, 2024    By - Dr Clemens
Candidate Kidney Protective Strategies for Patients Undergoing Major Abdominal Surgery

Authors: David R. McIlroy, M.D. et al  Anesthesiology June 2024, Vol. 140, 1111–1125. Background Acute kidney injury (AKI) is common after major abdominal surgery. Selection of candidate kidney protective strategies for testing in large trials should be based on robust preliminary evidence. Methods A secondary analysis of the Restrictive versus Liberal Fluid Therapy in Major Abdominal […]

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Uncategorized Published - 24 May, 2024    By - Dr Clemens
Variation in Hospital Neuraxial Labor Analgesia Rates in California

Authors: Pooja Parameshwar, M.D. et al  Anesthesiology June 2024, Vol. 140, 1098–1110. Background Neuraxial analgesia provides effective pain relief during labor. However, it is unclear whether neuraxial analgesia prevalence differs across U.S. hospitals. The aim of this study was to assess hospital variation in neuraxial analgesia prevalence in California. Methods A retrospective cross-sectional study analyzed birthing […]

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