Published in Anesth Analg. 2014 Jul;119(1):170-8 Authors: Sawynok J. et al Abstract Ketamine, in subanesthetic doses, produces systemic analgesia in chronic pain settings, an action largely attributed to block of N-methyl-D-aspartate receptors in the spinal cord and inhibition of central sensitization processes. N-methyl-D-aspartate receptors also are located peripherally on sensory afferent nerve endings, and this […]
Read MoreThe multifaceted problem of sharply rising opioid prescribing and related overdose deaths, which peaked in 2009, has been further analyzed by a research group in a recently published paper PM R 2014 Jan 9. The Stanford University team used 1997-2009 data from the large National Ambulatory and National Health Ambulatory Medical Care Surveys from the […]
Read MorePublished in Anesth Analg. 2014 Jul;119(1):137-40. Authors: Buck D et al Abstract An otherwise healthy 11-month-old, 8-kg infant presented for an elective circumcision. After a penile block with an excessive dose of 0.5% bupivacaine, the patient progressed to ventricular tachycardia. He was resuscitated with intralipid and had an uneventful recovery. The case was classified as […]
Read MoreLocal infiltration analgesia (LIA) provides effective analgesia early after total knee arthroplasty but has limited efficacy after total hip arthroplasty, according to results of a systematic review. “LIA should preferably be used in combination with evidence-based multimodal systemic analgesia,” Dr. Lasse O. Andersen from Bispebjerg Hospital in Copenhagen, Denmark told Reuters Health by email. “For […]
Read MoreBy implementing protocols that restrict the use of erythropoietin-stimulating agents (ESAs), hospitals can successfully cut costs while maintaining an equivalent level of patient care, according to two recent studies. At St. John Hospital and Medical Center in Detroit, a policy that delayed ESA administration to certain patients decreased ESA purchases by more than $16,000 per […]
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