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Anesthesiology Published - 9 April, 2026    By - Dr Clemens
Remifentanil–esketamine–based General Anesthesia Strategy for Microelectrode-guided Deep-brain Stimulation for Parkinson Disease

Authors: Huang D et al. Anesthesiology 144(4):1021–1024, April 2026 Summary:This prospective exploratory study evaluates a novel general anesthesia strategy using Remifentanil and Esketamine for deep-brain stimulation (DBS) surgery in patients with Parkinson disease. Traditionally, DBS electrode placement is performed under awake or lightly sedated conditions to preserve microelectrode recording signals, but this approach can be […]

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Anesthesiology Published - 9 April, 2026    By - Dr Clemens
Critical Closing and Tissue Perfusion Pressures in Sepsis: Implications for Risk Stratification

Authors: Wang J et al. Anesthesiology 144(4):886–897, April 2026 Summary:This large retrospective cohort study evaluates whether critical closing pressure (Pcc) and tissue perfusion pressure (TPP) provide better prognostic insight than mean arterial pressure (MAP) alone in patients with sepsis. While MAP has traditionally been the primary target for resuscitation, it does not fully capture the […]

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Anesthesiology Published - 9 April, 2026    By - Dr Clemens
Effect of Sevoflurane Concentration, Blood Pressure, Arterial Carbon Dioxide Tension, Temperature, and Stimulation on Spinal Cord Blood Flow in Patients Undergoing Spinal Surgery

Authors: Asif H et al. Anesthesiology 144(4):1012–1015, April 2026 Summary:This exploratory study examines how intraoperative variables affect spinal cord blood flow (SCBF) in humans using laser speckle contrast imaging, a technique that provides real-time, high-resolution perfusion mapping during spinal surgery. The key finding is that spinal cord blood flow behaves differently from cerebral blood flow […]

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Anesthesiology Published - 9 April, 2026    By - Dr Clemens
Minimum Alveolar Concentration Ratio Factors: Reply

Authors: Douville N et al. Anesthesiology 144(4):1026–1027, April 2026 Summary:This reply reinforces and expands on the argument that traditional hemodynamic parameters are inadequate for assessing anesthetic depth, agreeing with prior commentary that blood pressure and heart rate reflect secondary physiologic responses rather than direct brain effects. The authors emphasize that anesthetic depth should be grounded […]

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Anesthesiology Published - 9 April, 2026    By - Dr Clemens
Minimum Alveolar Concentration Ratio Factors: Comment

Authors: Muggleton E Anesthesiology 144(4):1025–1026, April 2026 Summary:This commentary challenges one of the most ingrained assumptions in anesthesiology—that hemodynamic stability reflects adequate depth of anesthesia. Building on prior research, the author argues that relying on blood pressure and heart rate as primary indicators of anesthetic depth is fundamentally flawed because these are indirect, downstream effects […]

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