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Anesthesiology Published - 10 April, 2026    By - Dr Clemens
Effects of Drug Treatments at High Temperatures: Comment

Authors: Kawashima S et al. Anesthesiology 144(4):1027–1028, April 2026 Summary:This letter critiques a prior in vitro study examining the effects of Propofol, Dexmedetomidine, and Acetaminophen on skeletal muscle under hyperthermic conditions. While acknowledging the mechanistic value of the work, the authors emphasize that several key limitations reduce its clinical applicability. The primary concern is the […]

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Anesthesiology Published - 10 April, 2026    By - Dr Clemens
Dabigatran in Sheep Cardiopulmonary Bypass: Reply

Authors: Eaton M et al. Anesthesiology 144(4):1029–1030, April 2026 Summary:This reply addresses concerns raised about the use of Dabigatran with Idarucizumab for cardiopulmonary bypass (CPB) anticoagulation. The authors acknowledge the limitations highlighted in the prior commentary and emphasize that this work remains in an early, preclinical stage of development. They agree that defining the minimum […]

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Anesthesiology Published - 10 April, 2026    By - Dr Clemens
Dabigatran in Sheep Cardiopulmonary Bypass: Comment

Authors: Zhu X et al. Anesthesiology 144(4):1028–1029, April 2026 Summary:This commentary evaluates a novel anticoagulation strategy for cardiopulmonary bypass (CPB) using Dabigatran with reversal by Idarucizumab. The authors highlight the potential importance of this approach, particularly for patients with heparin-induced thrombocytopenia, where current options are limited. The first major issue raised is dosing. Although the […]

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Anesthesiology Published - 10 April, 2026    By - Dr Clemens
Illustrating Bayesian Indices of Effect Existence and Practical Significance in Anesthesiology Trials

Authors: Huber M Anesthesiology 144(4):1016–1020, April 2026 Summary:This article introduces Bayesian statistical approaches as a complement to traditional frequentist methods in analyzing randomized controlled trials. It focuses on two key Bayesian indices—probability of direction and region of practical equivalence (ROPE)—to provide a more clinically meaningful interpretation of study results. The probability of direction reflects how […]

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Anesthesiology Published - 10 April, 2026    By - Dr Clemens
Returning to Anesthesia After Burnout, Pain Management, ICU med or administrative job? We Built a Path Back

Burnout or time away in pain, ICU, or administration doesn’t erase your anesthesia training—it just requires a structured path back. For many physicians, it simply means you stepped away to regroup. We work with anesthesiologists every day who want to return to clinical anesthesia after time away in: administration or leadership roles pain medicine critical […]

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