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Authors: Luiz F. Ferrari, DDS, PhD et al Anesthesiology June 2023. Background Chronic postsurgical pain (CPSP) is a poorly recognized outcome of surgery where patients experience pain long after healing from the surgical insult. Descending Control of Nociception (DCN), a phenomenon whereby application of a strong nociceptive stimulus to one part of the body of […]
Read MoreAuthors: Nasir Hussain, MD et al Anesthesiology June 2023. Background The analgesic effectiveness of contemporary motor-sparing nerve blocks used in combination for analgesia in total knee arthroplasty (TKA) is unclear. We conducted this network meta-analysis to evaluate the analgesic effectiveness of adding single-injection or continuous adductor canal block (ACB) with or without infiltration of the […]
Read MoreAuthors: Jacqueline M. Leung, M.D., M.P.H. et al Anesthesiology June 2023. Background The pathophysiology of delirium is incompletely understood including what molecular pathways are involved in brain vulnerability to delirium. We determined whether preoperative plasma neurodegeneration markers were elevated in patients who subsequently developed postoperative delirium through a retrospective case-control study. Methods Inclusion criteria were […]
Read MorePhillip E. Vlisides, M.D. et al Anesthesiology June 2023. Background Perioperative neurocognitive disorders are a major public health issue, though there are no validated neurophysiologic biomarkers that predict cognitive function after surgery. This study tested the hypothesis that preoperative posterior electroencephalographic alpha power, alpha frontal-parietal connectivity, and cerebral oximetry would each correlate with postoperative neurocognitive […]
Read MoreAutors: Christian Mpody, M.D., Ph.D., M.P.H., M.B.A. et al Anesthesiology July 2023, Vol. 139, 108–109. To the Editor: Although pharmaceutical costs account for approximately 15% of the overall cost of anesthetic care, these expenses are frequently assumed to be due to the choice of anesthetic technique (general vs. regional) or the choice of medications used for anesthetic […]
Read MoreAuthors: Eileen Nguyen, MD, PhD et al Anesthesiology June 2023. Background Pharmacological manipulations directed at the periaqueductal gray have demonstrated the importance of the mu-opioid receptor in modulating reflexive responses to nociception. We hypothesized that a supraspinal pathway centered on neurons in the periaqueductal gray containing the mu-opioid receptor could modulate nociceptive and itch behaviors. […]
Read MoreAuthors: Michael M. Todd, M.D.; Aaron F. Kopman, M.D. Anesthesiology July 2023, Vol. 139, 1–3. “Their observations […] indicate that clinicians who do not see the necessity for quantitative or objective neuromuscular monitoring when reversing residual block with sugammadex need to rethink their position.” In the current issue of Anesthesiology, Bowdle et al. report the results of an observational […]
Read MoreAuthor: Jeanna D. Blitz, M.D., F.A.S.A., D.F.P.M. Anesthesiology July 2023, Vol. 139, 91–103. The preanesthesia evaluation is the process of clinical assessment that precedes the delivery of anesthesia care. It provides the foundation for creating the perioperative anesthesia and pain management plan. The goal is to identify any factors that would prevent the patient from safely having […]
Read MoreAuthors: T. Andrew Bowdle, M.D., Ph.D., F.A.S.E. et al Anesthesiology July 2023, Vol. 139, 6–15. Background The dose of sugammadex recommended by the manufacturer for reversal of rocuronium is 2 mg/kg when the train-of-four count is 2 or more and 4 mg/kg when it is less than 2 but there is a posttetanic count of at least 1. […]
Read MoreAuthors: Patrick Forrest, MD et al ASA Monitor July 2023, Vol. 87, 1–5. Many readers may now be familiar with the new ASA practice guidelines for monitoring and antagonism of neuromuscular blockade that were published this past January (Anesthesiology 2023;138:13-41). For those who are not, this article may serve as a brief overview of the advances […]
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