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Published in J Clin Anesth, 2015 Authors: Khan JS et al STUDY OBJECTIVE: There exists no commonly accepted regimen for an intravenous lidocaine infusion (IVLI). This study aims to determine an appropriate end time for an IVLI during bowel surgery. DESIGN: A systematic search for randomized controlled trials assessing IVLI for bowel surgery was conducted using Ovid […]
Read MorePublished in J Clin Anesth, 2015 Sep Authors: Erdogan Ari D et al STUDY OBJECTIVE: To evaluate the effectiveness of 0.125% bupivacaine compared to 0.25% bupivacaine for ultrasound-guided transversus abdominis plane (TAP) block in patients undergoing open inguinal hernia repair. DESIGN: Randomized, double-blind study. SETTING: Educational and research hospital. PATIENTS: Forty adult patients of American Society of […]
Read MoreAnesthesia & Analgesia: November 2015 Vol 121 Issue 5 p 1157-1164 Authors: Kleine-Brueggeney, Maren MD et al BACKGROUND: Evidence suggests that cannabinoids can prevent chemotherapy-induced nausea and vomiting. The use of tetrahydrocannabinol (THC) has also been suggested for the prevention of postoperative nausea and vomiting (PONV), but evidence is very limited and inconclusive. To evaluate […]
Read MorePain Med,2015 Sep 23. Authors: Perloff MD et al OBJECTIVE: Gabapentin (GBP), originally an antiepileptic drug, is more commonly used in the treatment of pain, including headache disorders. Off-label GBP is used in headache disorders with some success, some failure, and much debate. Due to this ambiguity, a clinical evidence literature review was performed investigating GBP’s […]
Read MoreCrit Care, 2015 Sep 23;19(1):295. Authors: Pluims WA et al Endotracheal intubation is frequently complicated by laryngeal edema, which may present as postextubation stridor or respiratory difficulty or both. Ultimately, postextubation laryngeal edema may result in respiratory failure with subsequent reintubation. Risk factors for postextubation laryngeal edema include female gender, large tube size, and prolonged intubation. Although […]
Read MoreMedications play an important role in managing patients with opioid use disorders, but there are not enough physicians with the knowledge and ability to use these often-complex treatments. New evidence-based recommendations on the use of prescription medications for the treatment of opioid addiction are published in the October/November issue of the Journal of Addiction Medicine, the […]
Read MorePainful diabetic peripheral neuropathy (DPN) can be effectively treated with hepatocyte growth factor gene therapy, according to results of a phase 2 clinical trial presented at the 140th Annual Meeting of the American Neurological Association (ANA). “Diabetic peripheral neuropathy can cause debilitating pain with no effective treatment, and hepatocyte growth factor has potent neurotropic and […]
Read MoreVery low frequency (<2 Hz) stimulation may be more effective at controlling neuropathic pain in patients with spinal-cord injury than higher frequencies (>10 Hz), according to a small, 2-subject study presented on September 28 at the 140th Annual Meeting of the American Neurological Association (ANA). Corneliu Luca MD, PhD, University of Miami Health System, Miami, […]
Read MoreHeadache, 2015 Oct;55(9):1192-208. Authors: Johnson JL et al BACKGROUND: Medication overuse headache (MOH) is a condition bordering between a chronic pain condition and a substance dependence disorder. Activation of immunocompetent glial cells in the central nervous system has been linked to both pathological pain and drug addiction/reward. Preclinically, ibudilast attenuates glial activation and is able to reduce […]
Read MoreJ Arthroplasty, 2015 Sep;30 Authors: Schroer WC et al Liposomal bupivacaine periarticular injection (PAI) offers sustained bupivacaine release after TKA, but few prospective independent studies exist. In this prospective, blinded study, liposomal bupivacaine was randomized against bupivacaine and incorporated into a comprehensive multimodal pain management protocol. 111 primary TKAs were randomized to receive PAI: 58 patients received […]
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