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Edited by Susan Sadoughi, MD, and André Sofair, MD, MPH Elective sigmoidectomy is associated with improved quality of life for patients with recurrent and persistent symptoms after a diverticulitis episode, suggests an open-label trial in the Lancet Gastroenterology & Hepatology. Roughly 100 Dutch patients who’d had an episode of left-sided diverticulitis followed by either ongoing abdominal complaints lasting […]
Read MoreAuthors: Colin F. Royse, M.B.B.S., M.D., F.A.N.Z.C.A. et al Anesthesiology published on October 23, 2016 Background: Inflammation after cardiopulmonary bypass may contribute to postoperative delirium and cognitive dysfunction. The authors evaluated the effect of high-dose methylprednisolone to suppress inflammation on the incidence of delirium and postoperative quality of recovery after cardiac surgery. Methods: Five hundred fifty-five adults from […]
Read MoreAuthors: Lesley K. Rao, M.D. et al Anesthesiology published on October 23, 2016. Background: At therapeutic concentrations, cytochrome P4502B6 (CYP2B6) is the major P450 isoform catalyzing hepatic ketamine N-demethylation to norketamine in vitro. The CYP2B6 gene is highly polymorphic. The most common variant allele, CYP2B6*6, is associated with diminished hepatic CYP2B6 expression and catalytic activity compared with wild-type CYP2B6*1/*1. CYP2B6.6, […]
Read MoreAnesthesia & Analgesia: September 2016 – Volume 123 – Issue 3 – p 731–738 AUTHORS: Sigakis, Matthew J. G. MD et al BACKGROUND: Discharge diagnoses are used to track national trends and patterns of maternal morbidity. There are few data regarding the validity of the International Classification of Diseases (ICD) codes used for this purpose. The goal […]
Read MoreAnesthesia & Analgesia: September 2016 – Volume 123 – Issue 3 – p 715–721 AUTHORS: Schwartz, Lawrence I. MD et al BACKGROUND: Dexmedetomidine is a selective α-2 receptor agonist with a sedative and cardiopulmonary profile that makes it an attractive anesthetic for pediatric patients with congenital heart disease (CHD). Although several smaller, single-center studies suggest […]
Read MoreAnesthesia & Analgesia: September 2016 – Volume 123 – Issue 3 – p 705–714 AUTHORS: Chau, Destiny F. MD et al BACKGROUND: Complex surgical and critically ill pediatric patients rely on syringe infusion pumps for precise delivery of IV medications. Low flow rates and in-line IV filter use may affect drug delivery. To determine the […]
Read MoreAnesthesia & Analgesia: September 2016 – Volume 123 – Issue 3 – p 698–702 AUTHORS: Downing, John W. MD et al BACKGROUND: Vasoactive agents administered to counter maternal hypotension at cesarean delivery may theoretically intensify the hypoxemic fetoplacental vasoconstrictor response and, hence, negatively impact transplacental oxygen delivery to the fetus. Yet, this aspect of their […]
Read MoreAnesthesia & Analgesia:September 2016 – Volume 123 – Issue 3 – p 690–697 AUTHORS: Sviggum, Hans P. MD et al BACKGROUND: Intrathecal (IT) morphine is considered the “gold standard” for analgesia after cesarean delivery under spinal anesthesia, most commonly administered at a dose of 100 to 200 μg. There is less experience with IT hydromorphone […]
Read MoreAnesthesia & Analgesia: September 2016 – Volume 123 – Issue 3 – p 641–649 AUTHORS: Goldhaber-Fiebert, Sara N. MD et al BACKGROUND: Emergency manuals (EMs), context-relevant sets of cognitive aids or crisis checklists, have been used in high-hazard industries for decades, although this is a nascent field in health care. In the fall of 2012, […]
Read MoreAnesthesia & Analgesia: September 2016 – Volume 123 – Issue 3 – p 636–640 AUTHORS: Kim, Eugene MD et al BACKGROUND: It remains unclear whether we have to interrupt mechanical ventilation during infraclavicular subclavian venous catheterization. In practice, the clinicians’ choice about lung deflation depends on their own discretion. The purpose of this study was […]
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