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For the antifibrinolytic agent tranexamic acid, doses varying between 5 and 15 mg/kg failed to produce a dose-dependent drop in hemoglobin after total knee (TKA) or total hip arthroplasty (THA), leading study investigators to recommend using the lowest of these doses in orthopedic patients. “At my institution, we reviewed quite a bit of data while […]
Read MoreAnil Patel, MD, FRCA Consultant Anaesthetist Royal National Throat, Nose and Ear Hospital University College London Hospitals NHS Foundation Trust London, United Kingdom S.A. Reza Nouraei, MBBChir, PhD, FRCS Ear, Nose, and Throat Surgeon Honorary Senior Lecturer in Otolaryngology, University College London London, United Kingdom High-flow nasal oxygen optimizes preoxygenation and apnea time compared with […]
Read MoreThe US Food and Drug Administration (FDA) review has found that the growing combined use of opioid medicines with benzodiazepines or other drugs that depress the central nervous system (CNS) has resulted in serious side effects, including slowed or difficult breathing and deaths. In an effort to decrease the use of opioids and benzodiazepines, or […]
Read MoreNew research provides insight into a long-observed, but little-understood connection between chronic pain and anxiety and offers a potential target for treatment. The findings, published in Biological Psychiatry, showed that increased expression of a peptide neurotransmitter the body releases in response to stress — pituitary adenylate cyclase activating polypeptide (PACAP) — is also increased in […]
Read MoreAnesthesia & Analgesia: August 29, 2016 AUTHORS: Nasr, Viviane G. MD et al BACKGROUND: Although there have been numerous attempts to predict perioperative mortality in adults, an objective model to predict mortality in children has not been developed. In this study, we aimed to develop a Pediatric Risk Assessment (PRAm) score to predict perioperative mortality […]
Read MoreThe various predictive scoring systems range from fair to only moderately good, according to a new study in the journal Ambulatory Anesthesia. According to the authors multimodal approaches emphasizing prophylactic strategies that incorporate antiemetic medication, intravenous hydration and nonnarcotic analgesia appear promising, having been shown to reduce PONV from a norm of 20-30% to below 10%. The […]
Read MoreIncidence and Clinical Characteristics Authors: Hashem Abu-Arafeh; Ishaq Abu-Arafeh Objective To study the clinical and epidemiological characteristics of complex regional pain syndrome (CRPS) in children. Patients and methods All children and adolescents under 16 years of age with a new diagnosis of CRPS who were reported to the Scottish Paediatric Surveillance Unit were included. Patients’ […]
Read MoreIn Total Shoulder Arthroplasty: A large, retrospective study from Mayo Clinic has concluded that the addition of clonidine to a single-shot interscalene block does not improve the quality of analgesia in patients undergoing total shoulder arthroplasty. The study has helped clarify an issue that has had its supporters and detractors. The investigators noted, however, that […]
Read MorePatients with traumatic amputations resulting from land mine explosions show significant improvement in phantom limb pain after repetitive treatments of high-frequency transcranial stimulation (rTMS), new research shows. “Our study is the first randomized clinical trial demonstrating significant effects of transcranial magnetic stimulation in patients with phantom limb pain caused by traumatic amputations,” coauthor Ronald G. […]
Read MoreAs well as being opioid-sparing and curbing postoperative pain, preoperative pregabalin helps quell subsequent nausea and vomiting, according to a new meta-analysis. As Dr. Michael C. Grant told Reuters Health by email, “The findings of our review suggest that patients may benefit from the dual effects of drugs such as pregabalin. Providers who are already […]
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