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Researchers from the Technical University of Munich (TUM) claim to have discovered the molecular mechanism for the sedative thalidomide (Thalomid, Celgene). The findings could help to improve cancer treatment Nat Med. 2016 Jun 13. Thalidomide, an immunomodulatory drug developed in West Germany during the 1950s, was marketed in Europe as the first safe sleeping pill—even […]
Read MoreThe implementation of a multimodal analgesic protocol may be a simple, effective way to boost the documentation of preoperative pain scores and opioid use in an acute pain service, new research suggests. Multimodal protocols for nonopioid analgesia using acetaminophen, cyclooxygenase-2 inhibitors, gabapentinoids and peripheral nerve catheters have been shown to decrease opioid use and improve […]
Read MoreThe most recent data on obstetric lacerations during vaginal delivery have been incorporated into recommendations from the American College of Obstetricians and Gynecologists (ACOG), published in the July issue of Obstetrics & Gynecology. However, guidance on prevention and repair of severe perineal lacerations and on indications for episiotomy remains largely hampered by insufficient evidence. An estimated 53% to […]
Read MoreLevels of the inflammatory marker C-reactive protein (CRP) are significantly elevated in young adults with migraine, which may not only offer insights into the pathogenesis of the condition but also point to novel therapeutic avenues, researchers say. Delegates here at the American Headache Society (AHS) 58th Annual Scientific Meeting heard that levels of the protein, […]
Read MorePhysicians’ prescribing behavior may be influenced by their receipt of industry-sponsored meals, new data suggest. Physicians who received an industry-sponsored meal promoting a company’s drug were more likely to prescribe the brand-name drug than a less expensive generic one. “Physicians who received a single meal promoting the drug of interest had higher rates of prescribing […]
Read MoreThe FDA approved Probuphine (Titan/Braeburn), the first buprenorphine implant for the maintenance treatment of opioid dependence. Probuphine is designed to provide a constant, low-level dose of buprenorphine for six months in patients who are already stable on low-to-moderate doses of other forms of buprenorphine, as part of a complete treatment program. Until now, buprenorphine for […]
Read MoreAnesthesia & Analgesia: August 2016 – Volume 123 – Issue 2 – p 382–393 AUTHORS: Job, Kathleen M. PhD et al BACKGROUND: The endothelial glycocalyx is an important component of the vascular permeability barrier, forming a scaffold that allows serum proteins to create a gel-like layer on the endothelial surface and transmitting mechanosensing and mechanotransduction […]
Read MoreThe long-running debate about which surgical method is best for removing a cancerous prostate is over, a urologic surgeon declares in an editorial published in the July issue of the Journal of Urology. “Robotic prostatectomy has superior or at least equal oncologic efficacy and complication rates compared to open prostatectomy,” writes Michael O. Koch, MD, from the Indiana University […]
Read MoreBody mass index (BMI) is not as important to cancer outcomes as previously thought, according to the ABCPP (After Breast Cancer Pooling Project), which analyzed the effects of BMI, comorbidities and physical activity on mortality. Previous studies showed that being overweight increases breast cancer recurrence, breast cancer–specific mortality and overall mortality. The investigators used data […]
Read MoreThe Multidrug Resistant Organism Repository and Surveillance Network (MRSN) at the Walter Reed Army Institute of Research (WRAIR) characterized a transferable gene for colistin resistance in the United States that may herald the emergence of truly pan–drug-resistant bacteria (Antimicrob Agents Chemother2016 May 26. Colistin is the last agent used to combat bacteria that are resistant […]
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