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Uncategorized Published - 26 April, 2021    By - Dr Clemens
Analysis of Fentanyl Pharmacokinetics, and its Sedative Effects and Tolerance in Critically-Ill Children

DG Journal Club AUTHORS: Sin Yin Lim, Jamie L Miller et al. Pharmacotherapy. 2021 Feb 19 INTRODUCTION Fentanyl pharmacokinetic and pharmacodynamic data are limited in mechanically ventilated children. This study aims to assess the fentanyl pharmacokinetics (PK), the sedation outcome, and the development of tolerance in children receiving fentanyl continuous infusion. METHODS This study included […]

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Uncategorized Published - 26 April, 2021    By - Dr Clemens
Surgical risk scores may not be needed when considering TAVR

Author: Michael Walter Cardiovascular Business Clinicians may not necessarily need to assess a patient’s surgical risk when determining if they are a suitable candidate for transcatheter aortic valve replacement (TAVR), according to a new study published in Current Problems in Cardiology. Instead, that time could be spent focusing on other important considerations such as the patient’s […]

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Uncategorized Published - 26 April, 2021    By - Dr Clemens
Effects of general versus regional anaesthesia on circadian melatonin rhythm and its association with postoperative delirium in elderly patients undergoing hip fracture surgery

AUTHORS: Yi Yuan, Yanan Song et al. BMJ Open. 2021 Feb 12; 11(2): INTRODUCTION Postoperative delirium (POD) is a common neurological complication after hip fracture surgery and is associated with high morbidity and mortality in elderly patients. Although the specific mechanism of POD remains unclear, circadian rhythm disruptions have recently drawn increased attention. To date, […]

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Uncategorized Published - 26 April, 2021    By - Dr Clemens
Prophylactic norepinephrine infusion for postspinal anesthesia hypotension in patients undergoing cesarean section

DG Journal club AUTHORS: Yi Chen, Lili Zou et al. Pharmacotherapy. 2021 Feb 14 BACKGROUND Prophylactic norepinephrine infusion effectively lowers the incidence of postspinal anesthesia hypotension. The optimal prophylactic dose of norepinephrine remains undefined. The purpose of this study was to investigate the optimal prophylactic dose of norepinephrine to prevent postspinal anesthesia hypotension in patients […]

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Uncategorized Published - 23 April, 2021    By - Dr Clemens
Trigeminal neuralgia as the sole neurological manifestation of COVID-19

AUTHORS: Javier Molina-Gil, Lucía González-Fernández et al. Headache. 2021 03; 61(3): 560-562 OBJECTIVE To describe a case report of trigeminal neuralgia (TN) due to coronavirus disease-2019 (COVID-19). BACKGROUND In March 2020, the World Health Organization declared COVID-19 as a pandemic. Respiratory system manifestations are dominant in this new disease. However, numerous case series and reviews […]

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Uncategorized Published - 23 April, 2021    By - Dr Clemens
On Second Thought: Correcting the Anesthesia Record

Author: Tony Mira F1rstNews Summary What happens when you make a mistake in your medical record documentation?  Do you just write over it or, in the EMR context, simply hit delete and reenter?  What about the timing of the revision?  All these and other topics related to revising the anesthesia record are discussed in today’s […]

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Uncategorized Published - 23 April, 2021    By - Dr Clemens
Dexmedetomidine vs. Propofol for Sedation During Mechanical Ventilation

Patricia Kritek, MD, reviewing Hughes CG et al. N Engl J Med 2021 Feb 2 NEJM Journal Watch Key clinical outcomes were similar with either drug. Current best practice in the intensive care unit (ICU) is to use the least medication necessary to keep patients alert, interactive, and comfortable while they receive mechanical ventilation. Compared with propofol and […]

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Uncategorized Published - 23 April, 2021    By - Dr Clemens
Study suggests link between COVID-19 and subsequent neurological and psychiatric disorders

DG Alerts Coronavirus disease 2019 (COVID-19) was “robustly” associated with an increased risk of neurological and psychiatric disorders in the 6 months after a diagnosis, according to a study published in The Lancet Psychiatry. The study found that risks were greatest in, but not limited to, patients who had severe COVID-19. “To our knowledge, we provide […]

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Uncategorized Published - 22 April, 2021    By - Dr Clemens
Developmental innervation of cranial dura mater and migraine headache

AUTHORS: Andrew Witten, Dario Marotta et al. Headache. 2021 Mar 22 INTRODUCTION Migraine headache prevalence, etiology, and clinical presentations change from childhood to adulthood. Dural innervation plays a role in headache symptomatology, but the changes in innervation during development have not been fully explored in the literature. METHODS A narrative literature review on developmental innervation […]

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Uncategorized Published - 22 April, 2021    By - Dr Clemens
Deep Spinal Infection after Outpatient Epidural Injections for Pain: A Retrospective Sample Cohort Study Using a Claims Database in South Korea

Authors: Chang-Soon Lee, M.D. et al Anesthesiology April 2021 Background Deep spinal infection is a devastating complication after epidural injection. This study aimed to investigate the incidence of deep spinal infection primarily after outpatient single-shot epidural injection for pain. Secondarily, this study assessed the national trends of the procedure and risk factors for said infection. […]

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