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DG Alerts Use of therapeutic anticoagulation prior to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was associated with a lower risk for pulmonary embolism, but not a decreased risk for other coronavirus disease 2019 (COVID-19)-related outcomes in hospitalised COVID-19 patients, including in-hospital mortality, according to a study published in the British Journal of Clinical Pharmacology. […]
Read MoreAuthors: Jennifer J. Lee, M.D. et al Anesthesiology April 2021. Background The current American Society of Anesthesiologists fasting guideline for formula-fed infants in the periprocedural setting is 6 h. Prolonged fasting in very young infants is associated with an increased risk for hypoglycemia and dehydration as well as patient discomfort and patient/parental dissatisfaction. This study […]
Read MoreAuthors: Keith M. Vogt, M.D., Ph.D. et al Anesthesiology April 2021. Background Despite the well-known clinical effects of midazolam and ketamine, including sedation and memory impairment, the neural mechanisms of these distinct drugs in humans are incompletely understood. The authors hypothesized that both drugs would decrease recollection memory, task-related brain activity, and long-range connectivity between […]
Read MoreAuthors: Richard C. Prielipp, MD, MBA, FCCM and David J. Birnbach, MD, MPH ASA Monitor May 2021, Vol. 85, 44–45. Approximately 2 million hospitalized patients develop health care-associated infections (HCAI) annually, contributing to over 90,000 deaths each year in the United States (J Am Coll Surg 2017;225:455-64). While the source of these infections is complex and […]
Read MoreAuthors: Zhong-Hua Shi, M.D. et al Anesthesiology May 2021, Vol. 134, 748–759. Background The lateral abdominal wall muscles are recruited with active expiration, as may occur with high breathing effort, inspiratory muscle weakness, or pulmonary hyperinflation. The effects of critical illness and mechanical ventilation on these muscles are unknown. This study aimed to assess the reproducibility […]
Read MoreDG Journal Club AUTHORS: K Curtis, J Katz et al. Pain Med. 2021 Feb 16 OBJECTIVE To evaluate the feasibility and safety of hyperbaric oxygen therapy (HBOT) in patients with fibromyalgia (FM). DESIGN A cohort study with a delayed treatment arm used as a comparator. SETTING Hyperbaric Medicine Unit, Toronto General Hospital, Ontario, Canada. SUBJECTS […]
Read MoreAuthors: Qiliang Jiang, M.D. et al Anesthesiology May 2021, Vol. 134, 709–721. Background Whether supplemental oxygen worsens long-term mortality remains unclear, with contradictory trial results. The authors therefore tested the hypothesis that supplemental oxygen (80% vs. 30%) increases the hazard for long-term mortality. Methods The authors conducted a post hoc analysis of a large multiple crossover cluster trial in […]
Read MoreDG Journal Club AUTHORS: Sin Yin Lim, Jamie L Miller et al. Pharmacotherapy. 2021 Feb 19 INTRODUCTION Fentanyl pharmacokinetic and pharmacodynamic data are limited in mechanically ventilated children. This study aims to assess the fentanyl pharmacokinetics (PK), the sedation outcome, and the development of tolerance in children receiving fentanyl continuous infusion. METHODS This study included […]
Read MoreAuthor: Michael Walter Cardiovascular Business Clinicians may not necessarily need to assess a patient’s surgical risk when determining if they are a suitable candidate for transcatheter aortic valve replacement (TAVR), according to a new study published in Current Problems in Cardiology. Instead, that time could be spent focusing on other important considerations such as the patient’s […]
Read MoreAUTHORS: Yi Yuan, Yanan Song et al. BMJ Open. 2021 Feb 12; 11(2): INTRODUCTION Postoperative delirium (POD) is a common neurological complication after hip fracture surgery and is associated with high morbidity and mortality in elderly patients. Although the specific mechanism of POD remains unclear, circadian rhythm disruptions have recently drawn increased attention. To date, […]
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