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Uncategorized Published - 1 July, 2021    By - Dr Clemens
Effects of behavioural exercise therapy on the effectiveness of multidisciplinary rehabilitation for chronic non-specific low back pain

DG Journal Club AUTHORS: Jana Semrau, Christian Hentschke et al. BMC Musculoskelet Disord. 2021 May 29; 22(1): 500 BACKGROUND The long-term effects of behavioural medical rehabilitation (BMR), as a type of multidisciplinary rehabilitation, in the treatment of chronic non-specific low back pain (CLBP) have been shown. However, the specific effects of behavioural exercise therapy (BET) […]

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Uncategorized Published - 1 July, 2021    By - Dr Clemens
Possible immunoglobulin-E-dependent sugammadex-induced anaphylaxis caused by an epitope other than γ-cyclodextrin

DG Journal Club AUTHORS: Tatsuo Horiuchi, Tomonori Takazawa et al. J Med Case Rep. 2021 Jun 5; 15(1): 313 BACKGROUND Sugammadex is a synthetic γ-cyclodextrin derivative designed to selectively bind to steroidal neuromuscular blocking agents and reverse their effects. Although many cases of sugammadex-induced anaphylaxis have been reported, few studies have investigated the underlying mechanism. […]

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Uncategorized Published - 1 July, 2021    By - Dr Clemens
Effects of the ABCB1 c.3435C>T (rs1045642) Polymorphism on Heat Pain Perception in Opioid-Free Adults With Chronic Pain

AUTHORS: Hooten, W. Michael MD et al Anesthesia & Analgesia: June 2021 BACKGROUND: The adenosine triphosphate-binding cassette, subfamily B, member 1 gene (ABCB1) encodes P-glycoprotein (P-gp) that influences the intracellular transport of solutes including endogenous opioid peptides. The primary objective of this study was to determine the effects of the ABCB1 polymorphism c.3435C>T (rs10454642) on heat pain (HP) […]

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Uncategorized Published - 30 June, 2021    By - Dr Clemens
FDA approves first oral blood thinner for pediatric patients

Author: Michael Walter Cardiovascular Business The U.S. Food and Drug Administration has announced multiple new approvals for dabigatran etexilate—and it made a little bit of history along the way. Dabigatran etexilate, sold by Boehringer Ingelheim under the name Pradaxa, is now approved as a treatment option for venous thromboembolism in patients between the ages of […]

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Uncategorized Published - 30 June, 2021    By - Dr Clemens
Routine Postsurgical Anesthesia Visit to Improve 30-Day Morbidity and Mortality

DG Journal Club AUTHORS: Wolfgang F F A Buhre, Christa Boer et al. Ann Surg. 2021 May 24 OBJECTIVE To study the impact of a standardized postoperative anesthesia visit on 30-day mortality in medium to high-risk elective surgical patients. BACKGROUND Postoperative complications are the leading cause of perioperative morbidity and mortality. While modified early warning […]

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Uncategorized Published - 30 June, 2021    By - Dr Clemens
Quantitative Pupillometry as a Predictor of Pediatric Postoperative Opioid–Induced Respiratory Depression

AUTHORS: Packiasabapathy, Senthil MD et al Anesthesia & Analgesia: May 2021 BACKGROUND: Safe postoperative pain relief with opioids is an unmet critical medical need in children. There is a lack of objective, noninvasive bedside tool to assess central nervous system (CNS) effects of intraoperative opioids. Proactive identification of children at risk for postoperative respiratory depression (RD) […]

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Uncategorized Published - 30 June, 2021    By - Dr Clemens
Relationship Between Intraoperative and Preoperative Ambulatory Nighttime Heart Rates

AUTHORS: Kouz, Karim MD et al Anesthesia & Analgesia: June 2021 BACKGROUND: It remains unknown what constitutes physiologically relevant intraoperative bradycardia. Intraoperative bradycardia is usually defined using absolute heart rate thresholds, ignoring preoperative baseline heart rates. In contrast, we considered defining intraoperative bradycardia relative to preoperative ambulatory nighttime heart rate. Specifically, we hypothesized that the individual […]

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Uncategorized Published - 30 June, 2021    By - Dr Clemens
Driving Pressure–Guided Individualized Positive End-Expiratory Pressure in Abdominal Surgery

AUTHORS: Zhang, Chengmi MD, PhD et al Anesthesia & Analgesia: June 2021 BACKGROUND: The optimal positive end-expiratory pressure (PEEP) to prevent postoperative pulmonary complications (PPCs) remains unclear. Recent evidence showed that driving pressure was closely related to PPCs. In this study, we tested the hypothesis that an individualized PEEP guided by minimum driving pressure during abdominal […]

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Uncategorized Published - 29 June, 2021    By - Dr Clemens
Effectiveness of Perioperative Opioid Educational Initiatives

AUTHORS: Zorrilla-Vaca, Andres MD et al Anesthesia & Analgesia: June 2021 BACKGROUND: Opioids are the most commonly prescribed analgesics in the United States. Current guidelines have proposed education initiatives to reduce the risk of chronic opioid consumption, yet there is lack of efficacy data on such interventions. Our study evaluates the impact of perioperative opioid education […]

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Uncategorized Published - 29 June, 2021    By - Dr Clemens
Interleukin-6 Is an Early Plasma Marker of Severe Postoperative Complications in Thoracic Surgery

AUTHORS: Neff, Thomas A. MD et al Anesthesia & Analgesia: June 2021 BACKGROUND: Postoperative complications in surgery are a significant burden, not only for the patients but also economically. While several predicting factors have already been identified, it is still not well known if increased levels of inflammatory markers in the immediate perioperative phase correlate with […]

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