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Uncategorized Published - 29 June, 2021    By - Dr Clemens
Effectiveness of Perioperative Opioid Educational Initiatives

AUTHORS: Zorrilla-Vaca, Andres MD et al Anesthesia & Analgesia: June 2021 BACKGROUND: Opioids are the most commonly prescribed analgesics in the United States. Current guidelines have proposed education initiatives to reduce the risk of chronic opioid consumption, yet there is lack of efficacy data on such interventions. Our study evaluates the impact of perioperative opioid education […]

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Uncategorized Published - 29 June, 2021    By - Dr Clemens
Interleukin-6 Is an Early Plasma Marker of Severe Postoperative Complications in Thoracic Surgery

AUTHORS: Neff, Thomas A. MD et al Anesthesia & Analgesia: June 2021 BACKGROUND: Postoperative complications in surgery are a significant burden, not only for the patients but also economically. While several predicting factors have already been identified, it is still not well known if increased levels of inflammatory markers in the immediate perioperative phase correlate with […]

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Uncategorized Published - 29 June, 2021    By - Dr Clemens
The Facilitatory Effects of Adjuvant Pharmaceutics to Prolong the Duration of Local Anesthetic for Peripheral Nerve Block

AUTHORS: Xuan, Chengluan MD, PhD et al Anesthesia & Analgesia: June 2021 BACKGROUND: Peripheral nerve block (PNB) with perineural local anesthetic is used for anesthesia or analgesia with many benefits. To extend these benefits, various adjuvant drugs have been used to prolong the duration of analgesia. We aimed to evaluate the effectiveness of various adjuvants at […]

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Uncategorized Published - 29 June, 2021    By - Dr Clemens
Associations Between Preoperative Biomarkers and Cardiac Surgery–Associated Acute Kidney Injury in Elderly Patients

AUTHORS: Verwijmeren, Lisa MD, PhD et al Anesthesia & Analgesia: June 2021 BACKGROUND: Acute kidney injury (AKI) is associated with mortality after cardiac surgery. Novel risk factors may improve identification of patients at risk for renal injury. The authors evaluated the association between preoperative biomarkers that reflect cardiac, inflammatory, renal, and metabolic disorders and cardiac surgery–associated […]

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Uncategorized Published - 29 June, 2021    By - Dr Clemens
New metric identifies heart failure patients facing a higher risk of hospitalization or death

Author: Michael Walter Cardiovascular Business A new cardiac measurement obtained by wireless sensors in the pulmonary arteries could provide significant value for heart failure patients, according to a new analysis published in Heart, Lung and Circulation. This new measurement—pulmonary artery proportional pulse pressure (PAPP)—can be used to identify patients facing an especially high risk of hospitalization […]

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Uncategorized Published - 28 June, 2021    By - Dr Clemens
Differential Perioperative Outcomes in Patients With Obstructive Sleep Apnea, Obesity, or a Combination of Both Undergoing Open Colectomy

AUTHORS: Stundner, Ottokar MD, MBA et al Anesthesia & Analgesia: June 2021 BACKGROUND: An increasing body of evidence demonstrates an association between obstructive sleep apnea (OSA) and adverse perioperative outcomes. However, large-scale data on open colectomies are lacking. Moreover, the interaction of obesity with OSA is unknown. This study examines the impact of OSA, obesity, or […]

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Uncategorized Published - 28 June, 2021    By - Dr Clemens
Intrathecal 2-Chloroprocaine 3% Versus Hyperbaric Bupivacaine 0.75% for Cervical Cerclage

AUTHORS: Lee, Allison MD, MS et al Anesthesia & Analgesia: June 2021 BACKGROUND: Cervical cerclage is a short ambulatory procedure. For spinal anesthesia, local anesthetic agents with rapid postoperative resolution are desired. We hypothesized that in combination with fentanyl, intrathecal 2-chloroprocaine would produce earlier resolution of motor block, resulting in shorter time to meet recovery room […]

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Uncategorized Published - 28 June, 2021    By - Dr Clemens
P2Y1 Purinergic Receptor Contributes to Remifentanil-Induced Cold Hyperalgesia via Transient Receptor Potential Melastatin 8–Dependent Regulation of N-methyl-d-aspartate Receptor Phosphorylation in Dorsal Root Ganglion

AUTHORS: Su, Lin MD, PhD et al Anesthesia & Analgesia: June 2021 BACKGROUND: Remifentanil can induce postinfusion cold hyperalgesia. N-methyl-d-aspartate receptor (NMDAR) activation and upregulation of transient receptor potential melastatin 8 (TRPM8) membrane trafficking in dorsal root ganglion (DRG) are critical to cold hyperalgesia derived from neuropathic pain, and TRPM8 activation causes NMDAR-dependent cold response. Contribution of […]

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Uncategorized Published - 28 June, 2021    By - Dr Clemens
Outcome of Organ Dysfunction in the Perioperative Period

Authors: Thiele, Robert H. MD et al Anesthesia & Analgesia: June 2021 Abstract While intraoperative mortality has diminished greatly over the last several decades, the risk of death within 30 days of surgery remains stubbornly high and is ultimately related to perioperative organ failure. Perioperative strokes, while rare (<2% in noncardiac surgery), are associated with a […]

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Uncategorized Published - 28 June, 2021    By - Dr Clemens
Effect of Paratracheal Pressure on the Glottic View During Direct Laryngoscopy

AUTHORS: Won, Dongwook MD et al Anesthesia & Analgesia: June 2021 BACKGROUND: Cricoid pressure has been used as a component of the rapid sequence induction and intubation technique. However, concerns have been raised regarding the effectiveness and safety of cricoid pressure. Paratracheal pressure, a potential alternative to cricoid pressure to prevent regurgitation of gastric contents or […]

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