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Uncategorized Published - 2 June, 2023    By - Dr Clemens
Supply Chain Principles – A Primer for Anesthesiologists 2023

Authors: Korina Katsaliaki, PhD et al  ASA Monitor June 2023, Vol. 87, 21–23. During the last few years, there have been reports of shortages of anesthesiology supplies and drugs. These shortages have been caused by a combination of factors, including increased demand, manufacturing issues, and disruptions in the supply chain. For example, the use of propofol, […]

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Uncategorized Published - 2 June, 2023    By - Dr Clemens
Phosphorylated Upstream Frameshift 1–dependent Nonsense-mediated μ-Opioid Receptor mRNA Decay in the Spinal Cord Contributes to the Development of Neuropathic Allodynia–like Behavior in Rats 2023

Authors: Ming-Chun Hsieh, Ph.D. et al  Anesthesiology June 2023, Vol. 138, 634–655. Background Nonsense-mediated messenger RNA (mRNA) decay increases targeted mRNA degradation and has been implicated in the regulation of gene expression in neurons. The authors hypothesized that nonsense-mediated μ-opioid receptor mRNA decay in the spinal cord is involved in the development of neuropathic allodynia–like behavior […]

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Uncategorized Published - 1 June, 2023    By - Dr Clemens
National Drug Shortages – Broken Supply or Broken Chain? It Is Time to End the ‘Race to the Bottom’ 2023

Authors: Umar Kamal, MD et al  ASA Monitor June 2023, Vol. 87, 22–23. Albuterol, bupivacaine, hydrocortisone, and dopamine – these are only four of the approximately 260 drugs that have experienced national shortages over the past 12 months (asamonitor.pub/41eZ3Hx; asamonitor.pub/40TNKVa). These scarcities have led to treatment delays, rationing, and, in some cases, changes to therapeutic plans (asamonitor.pub/3mxTgh5). […]

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Uncategorized Published - 1 June, 2023    By - Dr Clemens
Health Care Wastage: An Affliction On Our Nation’s Health and Our Planet!

Author: Lalitha Sundararaman, MBBS, MD ASA Monitor June 2023, Vol. 87, 18–19. Health care expenditure (HCE) in the United States stands at around $4.3 trillion annually – about 18% of its gross domestic product (GDP) (JAMA 2019;322:1501-9). A study in JAMA revealed a startling fact about this remarkable number – that nearly 20%-30% of it is wasteful (JAMA […]

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Uncategorized Published - 1 June, 2023    By - Dr Clemens
First-Time Opioid Therapy: An Interactive Case History 2023

Authors: Bettinger J, Yaras R. Pract Pain Manage. 2023 MayJune:23(2). How to apply the updated CDC Clinical Practice Guideline for Prescribing Opioids for Pain in individuals starting opioid therapy. In this series of analyses, we have broken down the various aspects of the newly released revisions to the CDC Clinical Practice Guideline for Prescribing Opioids for Pain […]

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Uncategorized Published - 1 June, 2023    By - Dr Clemens
It’s Time for Hospital Workers to Identify and Eliminate Roadblocks to Reprocessing! 2023

Author: Daniel Vukelich, JD ASA Monitor June 2023, Vol. 87, 20. The February 2023 report issued by the U.N. Intergovernmental Panel on Climate Change stated that if human-caused global warming isn’t slowed to a couple tenths of a degree, deadly heat, drought, fires, and floods could impact the planet in “potentially irreversible” ways. Putting off cuts […]

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Uncategorized Published - 1 June, 2023    By - Dr Clemens
Hormones May Play a Role in Women’s Migraines 2023

Author: Heidi Splete Practical Pain Management May/June 2023 A new study explores the role of sex hormones and CGRP as a contributor to the higher prevalence of migraine in women compared to men. Migraine headaches are approximately three times more common in women than in men, but the prevalence of migraine in women decreases after […]

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Uncategorized Published - 31 May, 2023    By - Dr Clemens
Anesthesia Considerations for Radiation Therapy Patients 2021

Radius Anesthesia May blog Cancer treatment, including surgery, chemotherapy, and radiotherapy, results in major physiological and health changes. Impacts on everyday life can be significant and are relatively well-known. Impacts on other areas are also important. In particular, there are unique considerations for patients undergoing cancer treatment, especially radiation therapy, who need anesthesia. Chemotherapy can damage […]

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Uncategorized Published - 31 May, 2023    By - Dr Clemens
MY ANESTHESIOLOGIST ADMINISTERED FENTANYL TO ME. IS THAT OK? 2023

Author: Richard Novak MD THE ANESTHESIA CONSULTANT America is in the midst of a fentanyl crisis. There were 71,238 fentanyl overdose deaths in the United States in 2021. The Drug Enforcement Administration (DEA) states, “fentanyl is involved in more deaths of Americans under 50 than any cause of death, including heart disease, cancer, homicide, suicide and […]

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Uncategorized Published - 31 May, 2023    By - Dr Clemens
Is Continuous Intraoperative Monitoring of Mean Arterial Pressure as Good as the Hypotension Prediction Index Algorithm?: Research Letter 2023

Authors: Marijn P. Mulder, M.Sc. et al  Anesthesiology June 2023, Vol. 138, 657–658. To the Editor: The Hypotension Prediction Index is a validated machine learning algorithm based on numerous characteristics of the arterial waveform and aimed at predicting hypotension up to 15 min in advance.  The recent special article by Enevoldsen and Vistisen focused on the data selection […]

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