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Published in Br J Clin Pharmacol. 2014 Dec 30. Authors: Mouly S et AIMS: Methadone is characterized by wide intersubject variability regarding the dose needed to obtain full therapeutic response. We assessed the influence of sociodemographic, ethnic, clinical, metabolic & genotype variables on methadone maintenance dose requirement in opioid-dependent responder patients. METHODS: Eighty-one stable patients (60 […]
Read MorePublished in N Engl J Med. 2015 Jan 15;372(3):241-8 Authors: Dart RC et al BACKGROUND: The use of prescription opioid medications has increased greatly in the United States during the past two decades; in 2010, there were 16,651 opioid-related deaths. In response, hundreds of federal, state, and local interventions have been implemented. We describe trends in […]
Read MorePublished in Nations Health. 2014;44(7) Author: Lindsey Wahowiak A new report documenting pain and its treatment in America shows that only 15 states are doing well in helping Americans in pain. With most states failing to adequately address the issue, pain remains a huge public health issue. “Achieving Balance in State Pain Policy: A Progress Report […]
Read MorePublished in BMC Surg. 2014;14(41) Authors: Takanobu Yamada, et al Background Enhanced recovery after surgery (ERAS) programs have been reported to be feasible and useful for maintaining physiological function and facilitating recovery after colorectal surgery. The feasibility of such programs in gastric surgery remains unclear. This study assessed whether an ERAS program is feasible in patients who […]
Read MorePublished in Br J Anaesth. 2014;113(6):905-906. Authors: J. Moloney Accidents in complex systems occur through the concatenation of multiple factors; each may be necessary, but only when all are present are conditions sufficient to produce an accident. In 1990, James Reason, then a professor of Psychology at the University of Manchester, provided a crucial contribution to […]
Read MorePublished in BMC Anesthesiol. 2014;14(70) Authors: Rafael Jaimes, Angelo G Rocco Background: Epidural lipomatosis (EL) is an increase of adipose tissue, normally occurring in the epidural space, sufficient to distort the thecal sac and compress neural elements. There is a lack of knowledge of risk factors, impact on patient’s symptoms, and its possible association with epidural […]
Read MoreThere is insufficient evidence to determine the effectiveness of long-term opioid therapy for improving chronic pain, but emerging data support a dose-dependent risk for serious harms, such as overdose, mortality, and possibly fractures and cardiovascular events, according to a new review. Most opioid-related studies lasted less than 12 weeks (and many less than 6 weeks), […]
Read MorePublished in Clin Interv Aging. 2014 Dec 16;10:1-11 Authors: Guerriero F et al PURPOSE: Chronic pain is highly prevalent in older adults. Increasing evidence indicates strong opioids as a valid option for chronic pain management in geriatrics. The aim of this study was to evaluate efficacy and safety of low-dose oral prolonged-release oxycodone-naloxone (OXN-PR) in […]
Read MorePublished in Lancet Neurol. 2015 Feb;14(2):162-73 Authors: Finnerup NB et al BACKGROUND: New drug treatments, clinical trials, and standards of quality for assessment of evidence justify an update of evidence-based recommendations for the pharmacological treatment of neuropathic pain. Using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE), we revised the Special Interest Group on […]
Read MoreInterventional spine procedures have low same-day complication rates, according to an analysis of 26,151 such procedures performed at several centers in the United States. Less than 0.1% of the procedures resulted in a transfer to an emergency department (ED) or an aborted procedure, according to a presentation at the International Spine Intervention Society’s (ISIS) annual […]
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