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A retrospective comparison of infants and children sedated using propofol or dexmedetomidine has implicated propofol with the more rapid induction of anaesthesia and quicker recovery from sedation, researchers reported here at the 2015 Annual Meeting of the Pediatric Academic Societies (PAS). However, while propofol may be an alternative to dexmedetomidine, its benefits come with the […]
Read MoreOnabotulinumtoxinA produces significant pain relief in patients with cervical dystonia (CD) treated in US clinical practices, investigators reported on April 22 at the 67th Annual Meeting of the American Academy of Neurology (AAN). Atul T. Patel, MD, Kansas City Bone and Joint Clinic, Overland Park, Kansas, and colleagues elsewhere presented findings in 508 patients who […]
Read MoreAspirin before cardiac surgery significantly reduced postoperative permanent stroke and infectious endocarditis, a benefit that was not associated with increased risks for other potential adverse events. According to Vwaire J. Orhurhu, MPH, there is scant research in the effect of aspirin administration before cardiac surgery. He and his colleagues at Beth Israel Deaconess Medical Center […]
Read MoreAdding perineural dexamethasone as an adjunct to traditional brachial plexus block radically extends the duration of the block and improves postoperative pain outcomes, a meta-analysis has found. Additionally, no reports of persistent nerve injury were attributed to perineural dexamethasone administration in the nine trials comprising the analysis. “Our group has done quite a bit of […]
Read MoreAnesthesia & Analgesia: April 2015 Authors: Thonnerieux, Magalie MD et al BACKGROUND: Alveolar recruitment maneuvers (ARMs) are known to improve perioperative morbidity but can transiently impact cardiac output (CO). This reproducible hemodynamic perturbation creates a clinical opportunity to test multiple devices during acute changes in CO. The objective of this study was to evaluate the […]
Read MoreAnesthesia & Analgesia: July 2015 Volume 121 pages 159-164 Authors: Lavoie, Anne MD et al BACKGROUND: Prophylactic administration of oxytocin as a part of active management of the third stage of labor reduces the risk of postpartum hemorrhage. Prophylactic oxytocin is often administered as an infusion rather than a bolus. The aim of the current […]
Read MoreAnesthesia & Analgesia: July 2015 Volume 121 page 90-96 Authors: Borrat, Xavier MD et al BACKGROUND: The purpose of this study was to identify optimal target propofol and remifentanil concentrations to avoid a gag reflex in response to insertion of an upper gastrointestinal endoscope. METHODS: Patients presenting for endoscopy received target-controlled infusions (TCI) of both […]
Read MoreAnesthesia & Analgesia: July 2015 Volume 121 page 117-123 Authors: Berroa, Felicia MD, PhD et al BACKGROUND: The incidence of perioperative hypersensitivity reactions, which can be life-threatening, ranges from 1 in 20,000 to 1 in 1361. These reactions are usually classified as IgE or non-IgE mediated. The aim of this study was to determine the […]
Read MorePublished in Anesthesia & Analgesia: April 2015 Authors: Puri, Goverdhan D. MD, PhD et al BACKGROUND: Closed-loop systems for anesthesia delivery have been shown to outperform traditional manual control in different clinical settings. The present trial was aimed at evaluating the feasibility and efficacy of Bispectral Index (BISTM)-guided closed-loop anesthesia delivery system (CLADS) in comparison […]
Read MoreAnesthesia & Analgesia: April 2015 Issue 1 page 149-158 Authors: Heesen, Michael MD et al BACKGROUND: Patient-controlled epidural analgesia (PCEA) has gained popularity, but it is still unclear whether adding a background infusion confers any benefit. METHODS: A systematic literature search in PubMed, Embase, CINAHL, LILACS, CENTRAL, Clinicaltrials.gov, and ISI WOS was performed to identify […]
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