Anesthesiology

Anesthesiology Published - 9 January, 2026    By - Dr Clemens
Association between Multisite and Site-specific Chronic Pain, Analgesic Use, Metabolic–Proteomic Profile, and Incident Chronic Kidney Disease in Diabetes

Authors: Yang S et al. Journal: Anesthesiology, December 9, 2025. DOI: 10.1097/ALN.0000000000005829 SummaryThis large prospective cohort study examined the relationship between chronic pain patterns, analgesic use, and the development of chronic kidney disease (CKD) in individuals with diabetes, while also exploring associated metabolic and proteomic signatures. Given the high prevalence of chronic pain in diabetes […]

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Anesthesiology Published - 9 January, 2026    By - Dr Clemens
How 1 anesthesia leader plans to tackle workforce shortages in 2026

Author: Francesca Mathewes Becker’s ASC Review Leaders in anesthesia, especially those in the outpatient setting, are juggling numerous challenges amid workforce shortages, declining reimbursements and costly inefficiencies. Jeff Tieder, MSN, CRNA, a clinical assistant professor at the University of Tennessee at Chattanooga recently joined Becker’s to discuss his plans for combating the industry’s various challenges in 2026. Editor’s note: This […]

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Anesthesiology Published - 9 January, 2026    By - Dr Clemens
Single Muscle Fibre Calcium Wave Frequency Assay for Malignant Hyperthermia Diagnosis

Authors: Singh DP et al. Journal: Anesthesiology, December 5, 2025. DOI: 10.1097/ALN.0000000000005882 SummaryThis exploratory validation study evaluated a novel diagnostic approach for malignant hyperthermia (MH) susceptibility using a single muscle fiber calcium wave frequency assay (CaWFa). Given the limitations of the current gold standard in-vitro contracture test (IVCT), including invasiveness, tissue requirements, and indirect measurement […]

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Anesthesiology Published - 9 January, 2026    By - Dr Clemens
Modulation of pain sensitivity by the locus coeruleus–paraventricular thalamic nucleus–anterior cingulate cortex pathway in mice

Authors: Kuai S et al. Journal: Anesthesiology, December 11, 2025. DOI: 10.1097/ALN.0000000000005897 SummaryThis preclinical neurocircuitry study investigated how noradrenergic signaling from the locus coeruleus (LC) modulates pain sensitivity through distinct downstream pathways involving the paraventricular thalamic nucleus (PVA) and the anterior cingulate cortex (ACC). Although LC projections to both the thalamus and cortex are known […]

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Anesthesiology Published - 8 January, 2026    By - Dr Clemens
Sex-specific Effects of Acute Stress on Emergence from Isoflurane Anesthesia via Brainstem Circuitry in Mice

Authors: Zhao X et al. Journal: Anesthesiology, December 9, 2025. DOI: 10.1097/ALN.0000000000005826 SummaryThis preclinical mechanistic study investigated how acute stress alters anesthetic efficacy and emergence from isoflurane anesthesia, with a focus on sex-specific effects and underlying brainstem circuitry. Recognizing that preoperative stress contributes to variability in anesthetic depth and recovery, the authors aimed to define […]

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Anesthesiology Published - 8 January, 2026    By - Dr Clemens
Pain management’s evolving place in spine care

Author: Carly Behm Becker’s Spine Review In spine care, surgeons and nonsurgical pain management physicians have had some tensions over who addresses different procedures, especially as minimally invasive procedures become more widespread. However, interspecialty collaboration is becoming a bigger priority. William Mitchell, MD, president of the North American Spine Society, said this will be a […]

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Anesthesiology Published - 8 January, 2026    By - Dr Clemens
Suzetrigine for the Treatment of Acute Pain: Reply

Authors: Bertoch T et al. Journal: Anesthesiology, December 11, 2025. DOI: 10.1097/ALN.0000000000005825 SummaryThis reply addresses multiple commentaries regarding the clinical meaningfulness, demographic consistency, and comparative efficacy of suzetrigine for moderate-to-severe acute pain. The authors clarify points raised about subgroup effects, outcome interpretation, and comparison with established opioid analgesics. The authors emphasize that phase 3 randomized […]

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Anesthesiology Published - 8 January, 2026    By - Dr Clemens
Relationship between Ventilation/Perfusion Ratio Mismatch and Capnogram Phase III Slope in Acute Bronchoconstriction and Its Modulation by Salbutamol Assessed by Synchrotron Imaging in Rabbit Lung

Authors: Bayat S et al. Journal: Anesthesiology, December 12, 2025. DOI: 10.1097/ALN.0000000000005807 SummaryThis experimental physiologic study examined whether the slope of phase III of the volumetric capnogram (SIII) truly reflects ventilation–perfusion (V/Q) mismatch during acute bronchoconstriction and how this relationship is altered by bronchodilator therapy. Using a rabbit model and high-resolution synchrotron radiation imaging, the […]

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Anesthesiology Published - 8 January, 2026    By - Dr Clemens
BEST Independent CRNA Opportunity – Savannah, TN just increased salary $15,000

Hardin Medical Center (122 beds) is offering a rare CRNA-only practice where you can enjoy full autonomy and an exceptional lifestyle. • Schedule: 2 weeks on / 1 week off (17 weeks off each year)• Model: Independent CRNA practice – no anesthesiologist supervision• Case Mix: General surgery, orthopedics, endoscopy, OB/GYN (including epidurals & C-sections)• No […]

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Anesthesiology Published - 8 January, 2026    By - Dr Clemens
Suzetrigine for the Treatment of Acute Pain: Comment

Authors: Siddiqui A et al. Journal: Anesthesiology, February 2026 (accepted October 17, 2025). DOI: 10.1097/ALN.0000000000005828 SummaryThis letter to the editor provides a critical appraisal of recently published phase 3 trials evaluating suzetrigine for the treatment of moderate-to-severe acute pain. The authors focus on the interpretation of efficacy metrics and whether the reported outcomes meet accepted […]

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