Anesthesiology Published - 7 April, 2026 By - Dr Clemens

Frequency and Management of Maternal Peripartum Cardiac Arrest during Anesthetic Care

Authors: Furdyna M et al. Anesthesiology 144(4):796–810, April 2026 Summary:This large multicenter retrospective cohort study provides one of the most comprehensive evaluations of maternal cardiac arrest during peripartum anesthetic care in the United States. Using data from over 778,000 deliveries across 60 institutions, the authors identified 87 cases of maternal cardiac arrest, corresponding to an […]

Anesthesiology Published - 7 April, 2026 By - Dr Clemens

Evaluating the Statistical Robustness of Randomized Controlled Trials of Spinal Cord Stimulation for Pain through the Use of Fragility Index

Authors: Hussain N et al. Anesthesiology 144(4):898–912, April 2026 Summary:This study evaluates the strength of evidence supporting spinal cord stimulation (SCS) for chronic pain by applying the fragility index—a statistical measure that assesses how many outcome changes would be needed to overturn a trial’s results. Unlike traditional P values, the fragility index provides insight into […]

Anesthesiology Published - 7 April, 2026 By - Dr Clemens

Effects of Isoflurane Inhibition of Mitochondrial Complex I on Calcium Removal in Mouse Neuronal Cultures

Authors: Jung S et al. Anesthesiology 144(4):871–885, April 2026 Summary:This experimental study investigates a key mechanism behind anesthetic-induced neurotoxicity, focusing on how Isoflurane disrupts calcium regulation in neurons. The authors specifically examined whether impaired calcium removal—rather than increased calcium entry—drives neuronal injury. Using mouse neuronal cultures, the study demonstrated that isoflurane significantly prolongs the time […]

Anesthesiology Published - 7 April, 2026 By - Dr Clemens

Role of Dorsomedial Periaqueductal Gray Glutamatergic Neurons in Promoting Arousal under Multiple General Anesthetics in Mice

Authors: Tong L et al. Anesthesiology 144(4):853–870, April 2026 Summary:This mechanistic study investigates the role of glutamatergic neurons in the dorsomedial periaqueductal gray (dmPAG) as a potential common neural pathway regulating anesthesia and emergence. The periaqueductal gray has long been recognized for its role in pain and defensive behaviors, but its contribution to anesthesia–arousal transitions […]

Anesthesiology Published - 7 April, 2026 By - Dr Clemens

Returning to Anesthesia After Burnout, Pain Management, ICU med or administrative job? We Built a Path Back

Burnout or time away in pain, ICU, or administration doesn’t erase your anesthesia training—it just requires a structured path back. For many physicians, it simply means you stepped away to regroup. We work with anesthesiologists every day who want to return to clinical anesthesia after time away in: administration or leadership roles pain medicine critical […]

Anesthesiology Published - 7 April, 2026 By - Dr Clemens

BEST Independent CRNA Opportunity – Savannah, TN just increased salary $15,000

Hardin Medical Center (122 beds) is offering a rare CRNA-only practice where you can enjoy full autonomy and an exceptional lifestyle. • Schedule: 2 weeks on / 1 week off (17 weeks off each year)• Model: Independent CRNA practice – no anesthesiologist supervision• Case Mix: General surgery, orthopedics, endoscopy, OB/GYN (including epidurals & C-sections)• No […]

Anesthesiology Published - 6 April, 2026 By - Dr Clemens

Comparative Evaluation of Post-operative Analgesia Using Visual Analogue Score (VAS) With a Low Dose of Clonidine (0.5 mcg/kg) as an Adjuvant to 0.2% Ropivacaine in Ultrasound-Guided Supraclavicular Block in Upper Limb Surgeries

Authors: Sheoran B et al. Cureus 18(2): e104270, February 25, 2026 This prospective observational study evaluated whether adding low-dose clonidine (0.5 mcg/kg) to 0.2% ropivacaine prolongs postoperative analgesia in ultrasound-guided supraclavicular brachial plexus blocks for upper limb surgeries. Ninety adult patients were divided into two groups: ropivacaine alone (Group A, n=45) versus ropivacaine plus clonidine […]

Anesthesiology Published - 6 April, 2026 By - Dr Clemens

Individualized Perioperative Blood Pressure and Fluid Therapy in Esophagectomy

Authors: Hovgaard H et al. Anesthesiology 144(4):823–836, April 2026 Summary:This randomized controlled trial examined whether extending goal-directed fluid therapy (GDFT) beyond the operating room and individualizing blood pressure targets improves outcomes after esophagectomy. Patients were randomized to either standard care or an intervention strategy that optimized cardiac output and used each patient’s baseline nighttime mean […]

Anesthesiology Published - 6 April, 2026 By - Dr Clemens

Discordances between Preoperative Creatinine- and Cystatin C–based Estimated Glomerular Filtration Rate and Outcomes after Noncardiac Surgery

Authors: Lei S et al. Anesthesiology 144(4):811–822, April 2026 Summary:This large observational study evaluates the clinical significance of discordance between creatinine-based and cystatin C–based estimates of renal function in surgical patients. Using two large cohorts totaling nearly 59,000 patients undergoing major noncardiac surgery, the authors examined whether differences between these two measurements (eGFRdiff) predict postoperative […]

Anesthesiology Published - 6 April, 2026 By - Dr Clemens

Science, Medicine and the Anesthesiologist

Author: Mark D. Neuman, MD, M.Sc, Editor Anesthesiology, April 2026 Summary:This study explores a novel mechanism of peripheral pain modulation through glial cell signaling. Researchers showed that a diazepam-binding inhibitor (DBI) influences mechanosensation by acting on glial cells in dorsal root ganglia. Blocking DBI reduced neuronal excitability and decreased mechanical pain hypersensitivity in animal models. […]