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Uncategorized Published - 30 January, 2023    By - Dr Clemens
Prevention of Postoperative Cognitive Dysfunction by Minocycline in Elderly Patients after Total Knee Arthroplasty

Authors: Tomonori Takazawa, M.D., Ph.D. et al  Anesthesiology February 2023, Vol. 138, 172–183. Background There are no effective pharmacologic interventions for preventing postoperative cognitive dysfunction in daily practice. Since the antibiotic minocycline is known to suppress postoperative neuroinflammation, this study hypothesized and investigated whether minocycline might have a preventive effect on postoperative cognitive dysfunction after noncardiac […]

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Uncategorized Published - 30 January, 2023    By - Dr Clemens
Postoperative Acute Kidney Injury by Age and Sex

Authors: Jamie R. Privratsky, M.D., Ph.D. et al  Anesthesiology February 2023, Vol. 138, 184–194. Background Acute kidney injury (AKI) after noncardiac surgery is common and has substantial health impact. Preclinical and clinical studies examining the influence of sex on AKI have yielded conflicting results, although they typically do not account for age-related changes. The objective of […]

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Uncategorized Published - 27 January, 2023    By - Dr Clemens
Subcostal transversus abdominis plane block for postoperative analgesia in liver transplant recipients

AUTHORS: Mona Assefi, Emma Trillaud, Corinne Vezinet, Baptiste Duceau Reg Anesth Pain Med. 2023 Jan 17 INTRODUCTION Postoperative pain management after orthotopic liver transplantation is complex due to impaired liver function and frequent acute kidney dysfunction. Subcostal transversus abdominis plane (TAP) block may be of interest in this population. The aim of this study was […]

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Uncategorized Published - 27 January, 2023    By - Dr Clemens
Postoperative pulmonary complications in the ENIGMA II Trial

DG Journal Club AUTHORS: Philip J Peyton, Grace Liskaser, Alexander Ho, Harry Marsh Anesthesiology. 2023 Jan 16 BACKGROUND Nitrous oxide (N2O) promotes absorption atelectasis in poorly ventilated lung segments at high inspired concentrations. The ENIGMA Trial found a higher incidence of postoperative pulmonary complications (PPCs) and wound sepsis with N2O anesthesia in major surgery compared to […]

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Uncategorized Published - 27 January, 2023    By - Dr Clemens
Analgesics Drug Report 2022: The Pain Management Pipeline

Authors: Jacquot M et al Pract Pain Manag. 2023 January/February;23(1). In our 2022 drug report, we review emerging pain management agents, including CBD and THC preparations, nearing the market. Plus, a look at updated formulations in development for more targeted pain treatment. With more than 1 in 5 Americans experiencing chronic pain, pain management is […]

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