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Uncategorized Published - 2 October, 2023    By - Dr Clemens
Opposing effects on descending control of nociception by mu and kappa opioid receptors in the anterior cingulate cortex

Authors: Edita Navratilova, Ph.D. et al  Anesthesiology September 2023. Background The efficiency of descending pain modulation, commonly assessed with the conditioned pain modulation (CPM) procedure, is diminished in patients with chronic pain. We hypothesized that the efficiency of pain modulation is controlled by cortical opioid circuits. Methods We evaluated the effects of mu opioid receptor […]

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Uncategorized Published - 29 September, 2023    By - Dr Clemens
Intraoperative Hypotension: How Do We Fare in Lower Risk Surgeries and How Can We Improve?

Author: Wael Saasouh, MD IARS Newsletter Issue 4 Intraoperative hypotension has been shown to negatively influence patient outcomes based on large trials from major academic centers. During the session, “A Pragmatic Discussion on Intraoperative Hypotension” on Saturday, April 15 at the IARS 2023 Annual Meeting, experts on this topic shared the results of similar work […]

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Uncategorized Published - 29 September, 2023    By - Dr Clemens
Association Between Profound Shock Signs and Peripheral Intravenous Access Success Rates in Trauma Patients in the Prehospital Scenario

AUTHORS: Barsky, Daniel MD et al  Anesthesia & Analgesia 136(5):p 934-940, May 2023. BACKGROUND: Hemorrhage is the leading cause of preventable death in trauma patients, and establishment of intravenous (IV) access is essential for volume resuscitation, a key component in the treatment of hemorrhagic shock. IV access among patients in shock is generally considered more challenging, […]

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Uncategorized Published - 29 September, 2023    By - Dr Clemens
Study of the Relationship Between Liver Function Markers and Traumatic Rhabdomyolysis: A Retrospective Study of Hemorrhagic Patients Admitted to Intensive Care Unit in a Level I Trauma Center

AUTHORS: Martinez, Thibault MD et al  Anesthesia & Analgesia 136(5):p 842-851, May 2023. BACKGROUND: Traumatic rhabdomyolysis (RM) is common and contributes to the development of medical complications, of which acute renal failure is the best described. Some authors have described an association between elevated aminotransferases and RM, suggesting the possibility of associated liver damage. Our study […]

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Uncategorized Published - 29 September, 2023    By - Dr Clemens
Ultramassive Transfusion for Trauma in the Age of Hemostatic Resuscitation

AUTHORS: Muldowney, Maeve MB, BCh, BAO et al  Anesthesia & Analgesia 136(5):p 927-933, May 2023. BACKGROUND: Uncontrolled bleeding is a leading cause of death in trauma. In the last 40 years, ultramassive transfusion (UMT; ≥20 units of red blood cells [RBCs]/24 hours) for trauma has been associated with 50% to 80% mortality; the question remains as […]

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