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Uncategorized Published - 16 October, 2023    By - Dr Clemens
Opioid analgesia for acute low back pain and neck pain (the OPAL trial)

Authors: Caitlin M P Jones et al Lancet. 2023 Aug 19;402(10402):612 Background: Opioid analgesics are commonly used for acute low back pain and neck pain, but supporting efficacy data are scarce. We aimed to investigate the efficacy and safety of a judicious short course of an opioid analgesic for acute low back pain and neck pain. […]

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Uncategorized Published - 16 October, 2023    By - Dr Clemens
Effectiveness of Lumbar Cerebrospinal Fluid Drain Among Patients With Aneurysmal Subarachnoid Hemorrhage

Authors: Stefan Wolf et al JAMA Neurol 2023 Aug 1;80(8):833-842. Importance: After aneurysmal subarachnoid hemorrhage, the use of lumbar drains has been suggested to decrease the incidence of delayed cerebral ischemia and improve long-term outcome. Objective: To determine the effectiveness of early lumbar cerebrospinal fluid drainage added to standard of care in patients after aneurysmal subarachnoid hemorrhage. […]

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Uncategorized Published - 16 October, 2023    By - Dr Clemens
Association of Genetic Variants with Postsurgical Pain

Authors: Stephan G. Frangakis, M.D., Ph.D. et al  Anesthesiology September 2023. Background Postsurgical pain is a key component of surgical recovery. However, the genetic drivers of postsurgical pain remain unclear. A broad review and meta-analyses of variants of interest will help investigators understand the potential effects of genetic variation. Methods This article is a systematic […]

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Uncategorized Published - 16 October, 2023    By - Dr Clemens
Evaluation of malignant hyperthermia features in patients with pathogenic or likely pathogenic RYR1 variants disclosedthrough a population genomic screening program

Authors: Kristen D. Yu, M.S. et al  Anesthesiology October 2023. Background Malignant hyperthermia (MH) susceptibility is a heritable musculoskeletal disorder that can present as a potentially fatal hypermetabolic response to triggering anesthesia agents. Genomic screening for variants in MH-associated genes RYR1 and CACNA1S provides an opportunity to prevent morbidity and mortality. There are limited outcomes data from disclosing variants […]

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Uncategorized Published - 13 October, 2023    By - Dr Clemens
Recurrent Intraoperative Anesthesia Machine Malfunctions

Authors: David W. Corpman, MD; Linda L. Liu, MD Anesthesia Patient Safety Foundation Oct 2023 Intraoperative equipment failures are increasingly rare events, but may cause serious harm based on an analysis of the American Society of Anesthesiologists (ASA) Closed Claims database.1 Pre-anesthesia checkout procedures strive to make these events preventable, but certain failures cannot be prevented […]

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