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Uncategorized Published - 21 November, 2023    By - Dr Clemens
Dexmedetomidine Pretreatment Protects Against Myocardial Ischemia/Reperfusion Injury by Activating STAT3 Signaling

AUTHORS: Chen, Zhao-Rong MM et al  Anesthesia & Analgesia 137(2):p 426-439, August 2023. BACKGROUND: Myocardial infarction is a common perioperative complication, and blood flow restoration causes ischemia/reperfusion injury (IRI). Dexmedetomidine (DEX) pretreatment can protect against cardiac IRI, but the mechanism is still insufficiently understood. METHODS: In vivo, myocardial ischemia/reperfusion (30 minutes/120 minutes) was induced via ligation […]

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Uncategorized Published - 21 November, 2023    By - Dr Clemens
Project SPRUCE: Saving Our Planet by Reducing Carbon Emissions, a Pediatric Anesthesia Sustainability Quality Improvement Initiative

AUTHORS: Hansen, Elizabeth E. MD, PhD et al  Anesthesia & Analgesia 137(1):p 98-107, July 2023. BACKGROUND: Children are particularly vulnerable to adverse health outcomes related to climate change. Inhalational anesthetics are potent greenhouse gasses (GHGs) and contribute significantly to health care–generated emissions. Desflurane and nitrous oxide have very high global warming potentials. Eliminating their use, as […]

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Uncategorized Published - 21 November, 2023    By - Dr Clemens
Management of Muscle Relaxation With Rocuronium and Reversal With Neostigmine or Sugammadex Guided by Quantitative Neuromuscular Monitoring

AUTHORS: Thilen, Stephan R. MD, MS et al  Anesthesia & Analgesia May 12, 2023. BACKGROUND: The optimal pharmacological reversal strategy for neuromuscular blockade remains undefined even in the setting of strong recommendations for quantitative neuromuscular monitoring by several national and international anesthesiology societies. We evaluated a protocol for managing rocuronium blockade and reversal, using quantitative […]

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Uncategorized Published - 20 November, 2023    By - Dr Clemens
Tracheal Narrowing and Its Impact on Anesthesia Care in Patients With Morquio A (Mucopolysaccharidosis Type IVA)

AUTHORS: Theroux, Mary C. MD et al  Anesthesia & Analgesia 137(5):p 1075-1083, November 2023. BACKGROUND:  Recently, tracheal narrowing has been recognized as a significant comorbid condition in patients with Morquio A, also known as mucopolysaccharidosis IVA. We studied a large cohort of patients with Morquio A to describe the extent of their tracheal narrowing and its […]

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Uncategorized Published - 20 November, 2023    By - Dr Clemens
The Timing of Initiating Hydrocortisone and Long-term Mortality in Septic Shock

AUTHORS: Zhang, Luming MD, PhD et al  Anesthesia & Analgesia 137(4):p 850-858, October 2023. BACKGROUND: Previous studies on the association between the timing of corticosteroid administration and mortality in septic shock focused only on short-term mortality and produced conflicting results. We performed a retrospective review of a large administrative database of intensive care unit (ICU) patients […]

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