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AUTHORS: Okada, Carol R. MD et al Anesthesia & Analgesia 138(1):p 99-107, January 2024. BACKGROUND: Childhood obesity is a significant problem. Obesity may alter the pharmacokinetics (PKs) of medications. Fentanyl is commonly used for procedural sedation, but there is a paucity of bolus dose fentanyl PK data in obese children. Better understanding of fentanyl PK in […]
Read MoreAUTHORS: L. JOSEPH PARKER, MD KevinMD.com She walked in with a cane, bent over like a question mark. She was in her seventies and as sweet as people in that age group tend to be. I think most of the cranky ones don’t make it that far. She was something of an emergency because her […]
Read MoreAUTHORS: Lohela, Terhi J. MD, PhD et al Anesthesia & Analgesia 138(3):p 598-606, March 2024. BACKGROUND: Subanesthetic ketamine may reduce perioperative consumption of opioids. We studied whether intravenous S-ketamine alters the pharmacokinetics of oral morphine in healthy volunteers. METHODS: In this paired, randomized, double-blind, crossover trial, 12 participants under a 2-hour intravenous S-ketamine (0.57 mg/kg/h) […]
Read MoreAUTHORS: Dexter, Franklin MD, PhD, FASA*; Epstein, Richard H. MD, FASA† Anesthesia & Analgesia 137(5):p 1104-1109, November 2023. BACKGROUND: Sevoflurane and desflurane are halogenated hydrocarbons with global warming potential. We examined the maximum potential benefit assuming 100% efficiency of waste gas capture technology used in operating rooms and recovery locations. METHODS: We performed computer simulations […]
Read MoreAUTHORS: Saengsin, Kwannapas MD et al Anesthesia & Analgesia 137(5):p 1056-1065, November 2023. BACKGROUND: Phosphodiesterase inhibitors are known to relieve symptoms in the setting of heart failure, although their effects in restrictive ventricular physiology have been poorly characterized. We explored the association between the use of milrinone and volume administration during the first 72 hours following […]
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