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Anesthesiology Published - 12 January, 2026    By - Dr Clemens
Saccade tasks: A non-invasive approach for predicting postoperative delirium in elderly arthroplasty patients

Authors: Kang M et al. Journal: Anesthesiology, December 4, 2025. DOI: 10.1097/ALN.0000000000005875 SummaryThis prospective observational study evaluated whether preoperative saccadic eye movement tasks can serve as a noninvasive and accurate predictor of postoperative delirium (POD) in elderly patients undergoing arthroplasty. Given the limitations of traditional cognitive screening tools and invasive biomarker testing, the authors sought […]

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Anesthesiology Published - 12 January, 2026    By - Dr Clemens
Pain as a Driver of Myocardial Injury in Hip Fracture Patients: A Hip Fracture Accelerated Surgical Treatment and Care Track (HIP ATTACK) Trial Secondary Analysis

Authors: Khan JS et al. Journal: Anesthesiology, December 4, 2025. DOI: 10.1097/ALN.0000000000005818 SummaryThis prespecified secondary analysis of the HIP ATTACK randomized trial examined whether perioperative pain severity is associated with myocardial injury and ischemic events in patients undergoing hip fracture surgery. Hip fracture patients are particularly vulnerable to cardiovascular complications, and uncontrolled pain may provoke […]

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Anesthesiology Published - 12 January, 2026    By - Dr Clemens
Effects of repeated early life anesthesia exposure on visual system development in mice.

Authors: Seillier C et al. Journal: Anesthesiology, December 4, 2025. DOI: 10.1097/ALN.0000000000005879 SummaryThis preclinical study examined the effects of repeated early-life exposure to general anesthesia on visual system development in mice and explored the role of tissue-type plasminogen activator (tPA) as a potential mechanistic mediator. Given ongoing concerns about neurodevelopmental consequences of pediatric anesthesia—and prior […]

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Anesthesiology Published - 9 January, 2026    By - Dr Clemens
Critical Closing and Tissue Perfusion Pressures in Sepsis—Implications for Risk Stratification

Authors: Wang J-Y et al. Journal: Anesthesiology, December 5, 2025. DOI: 10.1097/ALN.0000000000005881 SummaryThis large retrospective cohort study evaluated whether critical closing pressure (Pcc) and tissue perfusion pressure (TPP) improve prognostication and risk stratification in patients with sepsis beyond mean arterial pressure (MAP) alone. While MAP is the cornerstone hemodynamic target in sepsis management, it does […]

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Anesthesiology Published - 9 January, 2026    By - Dr Clemens
Association between Multisite and Site-specific Chronic Pain, Analgesic Use, Metabolic–Proteomic Profile, and Incident Chronic Kidney Disease in Diabetes

Authors: Yang S et al. Journal: Anesthesiology, December 9, 2025. DOI: 10.1097/ALN.0000000000005829 SummaryThis large prospective cohort study examined the relationship between chronic pain patterns, analgesic use, and the development of chronic kidney disease (CKD) in individuals with diabetes, while also exploring associated metabolic and proteomic signatures. Given the high prevalence of chronic pain in diabetes […]

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