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Anesthesiology Published - 13 March, 2026    By - Dr Clemens
Modulation of Pain Sensitivity by the Locus Coeruleus–Paraventricular Thalamic Nucleus–Anterior Cingulate Cortex Pathway in Mice

Authors: Kuai S et al. Anesthesiology 144(4):943–964, April 2026 Summary:This study investigates how higher brain circuits regulate pain, focusing on a specific pathway connecting the locus coeruleus (LC), paraventricular thalamic nucleus (PVA), and anterior cingulate cortex (ACC). While the LC is known to modulate pain through noradrenergic signaling, the exact organization of its downstream pathways […]

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Anesthesiology Published - 12 March, 2026    By - Dr Clemens
Potential Mitochondrial Pharmacogenetic Susceptibility to Severe Neurologic Events after General Anesthesia

Authors: Yanez Hinojosa C I et al. Anesthesiology, February 18, 2026. Potential Mitochondrial Pharmacogenetic Susceptibility to Severe Neurologic Events after General Anesthesia: Report from the Chilean Ministry of Health. This report describes a cluster of severe neurologic complications that occurred after general anesthesia in previously healthy patients in Chile. The cases prompted a national investigation […]

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Anesthesiology Published - 12 March, 2026    By - Dr Clemens
Overdose propofol emulsion induces PANoptosis in human peripheral neutrophils in an ex vivo model

Authors: Lin M-C et al. Anesthesiology, February 12, 2026. Overdose propofol emulsion induces PANoptosis in human peripheral neutrophils in an ex vivo model. This experimental study investigated the cellular mechanisms underlying propofol infusion syndrome (PRIS), focusing on how high doses of propofol emulsion affect human neutrophils. Propofol is widely used for anesthesia and sedation, but […]

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Anesthesiology Published - 12 March, 2026    By - Dr Clemens
Strengthening the Evidence on Intraoperative Occult Hypoxemia

Authors: Wang W et al. Anesthesia & Analgesia, 2026. Strengthening the Evidence on Intraoperative Occult Hypoxemia. This letter to the editor discusses methodological considerations related to a recent study examining intraoperative occult hypoxemia and its association with postoperative mortality. Occult hypoxemia refers to a condition in which arterial oxygen saturation measured by pulse oximetry appears […]

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Anesthesiology Published - 12 March, 2026    By - Dr Clemens
Interpreting Length-of-Stay Benefits of Intrathecal Morphine in Modern Enhanced Recovery After Surgery Pathways

Authors: Wang L et al. Anesthesia & Analgesia, 2026. Interpreting Length-of-Stay Benefits of Intrathecal Morphine in Modern Enhanced Recovery After Surgery Pathways. This letter to the editor discusses the interpretation of a randomized controlled trial evaluating the effect of intrathecal morphine (ITM) on hospital length of stay after joint arthroplasty within enhanced recovery after surgery […]

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