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Uncategorized Published - 12 November, 2025    By - Dr Clemens
The Impact of Preoperative Functional Capacity on Postoperative Mortality and Morbidity

Authors: Valadkhani, Arman et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005779 This large prospective cohort study evaluated the relationship between preoperative functional capacity—measured in metabolic equivalents of task (METs)—and postoperative outcomes across a broad elective surgical population. While functional capacity is a cornerstone of preoperative risk assessment, this study explored its predictive value using granular […]

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Uncategorized Published - 12 November, 2025    By - Dr Clemens
Efficacy and safety of preemptive magnesium sulfate infusion during pheochromocytoma and paraganglioma resection

Authors: Kong, Hao et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005778 This randomized, double-blind, placebo-controlled trial assessed whether preemptive magnesium sulfate infusion can improve intraoperative hemodynamic stability in patients undergoing pheochromocytoma or paraganglioma (PPGL) resection—procedures known for extreme fluctuations in blood pressure and heart rate due to catecholamine release. Ninety-two patients scheduled for PPGL surgery […]

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Uncategorized Published - 12 November, 2025    By - Dr Clemens
Mixed-Methods Analysis of Preoperative Distress and Postoperative Outcomes in a Prospective, Observational Cohort of Older Adults

Authors: Kjaerulff, Isabella et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005780 This prospective mixed-methods study explored the relationship between preoperative psychological distress and postoperative outcomes in older adults undergoing noncardiac, nonneurosurgical procedures. Despite growing recognition that emotional well-being influences recovery, routine distress screening has not yet been integrated into most preoperative assessments. A total of […]

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Uncategorized Published - 12 November, 2025    By - Dr Clemens
General anesthesia and systemic hyperosmolality modulate lumbar intrathecal drug distribution in female rats

Authors: Persson, Niklas Daniel Åke et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005794 This preclinical imaging study investigated how anesthesia type and systemic hyperosmolality affect the central nervous system (CNS) distribution of intrathecally administered drugs. The researchers examined the pharmacokinetics of a high–molecular weight spinal tracer (technetium-99m–labeled human serum albumin nanocolloid, 66.5 kDa) in female […]

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Uncategorized Published - 12 November, 2025    By - Dr Clemens
Cannabis Extract Relieves Chronic Low Back Pain: Phase 3 Study

Edited by Melissa Warburg Medscape A recent phase 3 study of more than 800 adults, published in Nature, revealed encouraging results for a cannabis extract in treating chronic low back pain, offering new hope for patients seeking nonopioid relief. VER-01, a full-spectrum Cannabis sativa extract, provided sustained pain reduction while also improving sleep quality and physical function, and without requiring […]

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