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Anesthesiology Published - 10 April, 2026    By - Dr Clemens
Incidence of Pain during Cesarean Delivery with Neuraxial Anesthesia

Authors: O’Carroll J et al. Anesthesiology 144(4):784–795, April 2026 Summary:This large prospective multicenter cohort study provides one of the most definitive assessments to date of intraoperative pain during cesarean delivery under neuraxial anesthesia. Across 15 centers in the United States and Canada, nearly 3,700 patients were surveyed on postoperative day 1, capturing patient-reported pain and […]

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Anesthesiology Published - 10 April, 2026    By - Dr Clemens
Effects of Drug Treatments at High Temperatures: Comment

Authors: Kawashima S et al. Anesthesiology 144(4):1027–1028, April 2026 Summary:This letter critiques a prior in vitro study examining the effects of Propofol, Dexmedetomidine, and Acetaminophen on skeletal muscle under hyperthermic conditions. While acknowledging the mechanistic value of the work, the authors emphasize that several key limitations reduce its clinical applicability. The primary concern is the […]

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Anesthesiology Published - 10 April, 2026    By - Dr Clemens
Dabigatran in Sheep Cardiopulmonary Bypass: Reply

Authors: Eaton M et al. Anesthesiology 144(4):1029–1030, April 2026 Summary:This reply addresses concerns raised about the use of Dabigatran with Idarucizumab for cardiopulmonary bypass (CPB) anticoagulation. The authors acknowledge the limitations highlighted in the prior commentary and emphasize that this work remains in an early, preclinical stage of development. They agree that defining the minimum […]

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Anesthesiology Published - 10 April, 2026    By - Dr Clemens
Dabigatran in Sheep Cardiopulmonary Bypass: Comment

Authors: Zhu X et al. Anesthesiology 144(4):1028–1029, April 2026 Summary:This commentary evaluates a novel anticoagulation strategy for cardiopulmonary bypass (CPB) using Dabigatran with reversal by Idarucizumab. The authors highlight the potential importance of this approach, particularly for patients with heparin-induced thrombocytopenia, where current options are limited. The first major issue raised is dosing. Although the […]

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Anesthesiology Published - 10 April, 2026    By - Dr Clemens
Illustrating Bayesian Indices of Effect Existence and Practical Significance in Anesthesiology Trials

Authors: Huber M Anesthesiology 144(4):1016–1020, April 2026 Summary:This article introduces Bayesian statistical approaches as a complement to traditional frequentist methods in analyzing randomized controlled trials. It focuses on two key Bayesian indices—probability of direction and region of practical equivalence (ROPE)—to provide a more clinically meaningful interpretation of study results. The probability of direction reflects how […]

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