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Uncategorized Published - 17 February, 2015    By - Dr Clemens
Transfusion Threshold for Abdominal Cancer Surgery Patients

Published in Anesthesiology 2015 Jan 122:29 Authors: Pinheiro de Almeida J et al. A hemoglobin level of 9 g/dL was superior to 7 g/dL as a trigger for transfusion. Randomized trials have shown favorable outcomes with a restrictive red-cell transfusion strategy — that is, not transfusing until hemoglobin levels are <7 g/dL in general critical-care […]

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Uncategorized Published - 16 February, 2015    By - Dr Clemens
Ketorolac Tromethamine Injection by Hospira: Recall – Particulate in Glass Vials

Food and Drug Administration (US) AUDIENCE: Pharmacy, Case Manager ISSUE: Hospira announced a voluntary recall of ketorolac tromethamine injection, USP in the United States and Singapore due to potential particulate. The presence of particulate has been confirmed through a customer report of visible, floating particulate identified in glass fliptop vials. The particulate was identified as […]

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Uncategorized Published - 16 February, 2015    By - Dr Clemens
Structural Comparisons of Ligand-gated Ion Channels in Open, Closed, and Desensitized States Identify a Novel Propofol-binding Site on Mammalian γ-Aminobutyric Acid Type A Receptors

Published in The Journal of the American Society of Anesthesiologists on 1 2015. Authors: Nicholas P. Franks, F.R.C.A., F.Med.Sci., F.R.S. Background: Most anesthetics, particularly intravenous agents such as propofol and etomidate, enhance the actions of the neurotransmitter γ-aminobutyric acid (GABA) at the GABA type A receptor. However, there is no agreement as where anesthetics bind […]

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Uncategorized Published - 16 February, 2015    By - Dr Clemens
Repeated Exposure to Ketamine–Xylazine during Early Development Impairs Motor Learning–dependent Dendritic Spine Plasticity in Adulthood

Published in The Journal of the American Society of Anesthesiologists on 1 2015. Authors: Lianyan Huang, Ph.D.; Guang Yang, Ph.D. Background: Recent studies in rodents suggest that repeated and prolonged anesthetic exposure at early stages of development leads to cognitive and behavioral impairments later in life. However, the underlying mechanism remains unknown. In this study, […]

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Uncategorized Published - 16 February, 2015    By - Dr Clemens
Using Next-generation RNA Sequencing to Examine Ischemic Changes Induced by Cold Blood Cardioplegia on the Human Left Ventricular Myocardium Transcriptome

Published in The Journal of the American Society of Anesthesiologists in 1 2015. Authors: Jochen D. Muehlschlegel, M.D. et al Danos C. Christodoulou, Ph.D. Background: The exact mechanisms that underlie the pathological processes of myocardial ischemia in humans are unclear. Cardiopulmonary bypass with cardioplegic arrest allows the authors to examine the whole transcriptional profile of […]

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