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Uncategorized Published - 16 February, 2015    By - Dr Clemens
Repeated Exposure to Ketamine–Xylazine during Early Development Impairs Motor Learning–dependent Dendritic Spine Plasticity in Adulthood

Published in The Journal of the American Society of Anesthesiologists on 1 2015. Authors: Lianyan Huang, Ph.D.; Guang Yang, Ph.D. Background: Recent studies in rodents suggest that repeated and prolonged anesthetic exposure at early stages of development leads to cognitive and behavioral impairments later in life. However, the underlying mechanism remains unknown. In this study, […]

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Uncategorized Published - 16 February, 2015    By - Dr Clemens
Using Next-generation RNA Sequencing to Examine Ischemic Changes Induced by Cold Blood Cardioplegia on the Human Left Ventricular Myocardium Transcriptome

Published in The Journal of the American Society of Anesthesiologists in 1 2015. Authors: Jochen D. Muehlschlegel, M.D. et al Danos C. Christodoulou, Ph.D. Background: The exact mechanisms that underlie the pathological processes of myocardial ischemia in humans are unclear. Cardiopulmonary bypass with cardioplegic arrest allows the authors to examine the whole transcriptional profile of […]

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Uncategorized Published - 16 February, 2015    By - Dr Clemens
Enhanced Effects of Isoflurane on the Long QT Syndrome 1–associated A341V Mutant

Authors: Ikuomi Mikuni, M.D., Ph.D. et al Published in The Journal of the American Society of Anesthesiologists on 1 2015. Background: The impact of volatile anesthetics on patients with inherited long QT syndrome (LQTS) is not well understood. This is further complicated by the different genotypes underlying LQTS. No studies have reported on the direct […]

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Uncategorized Published - 13 February, 2015    By - Dr Clemens
Comparative Effects of Morning vs Evening Dosing of Extended-Release Hydromorphone on Sleep Physiology in Patients with Low Back Pain: A Pilot Study

Authors: Webster L, Smith M, Mackin S, Iverson M Published in Pain Medicine (Oct 2014) OBJECTIVE To investigate effects of extended-release (ER) hydromorphone dosing time (morning, QAM; evening, QPM) on sleep physiology in patients with chronic low back pain. DESIGN Randomized, double-blind, placebo-controlled, crossover trial. SETTING Clinical research site. PATIENTS Fifteen patients with moderate-to-severe chronic low […]

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Uncategorized Published - 13 February, 2015    By - Dr Clemens
Nocebo effects and negative suggestion in anesthesia

Published in Der Anaesthesist (Oct 2014) Authors: Zech N, Seemann M, Hansen E; Anesthetists have an impact on patients and healing processes not only through drugs, interventions and therapy but also significantly by their words and personality. A substantial part of observed side effects is caused by nocebo effects and negative suggestion, i.e. by the doctor […]

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