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Published in Anesthesiology Newly Published on 3 2015. Authors: François Gaudreault, B.Sc., Ph.D. et al Background: Even though ropivacaine is frequently used during orthopedic surgery, the relationship between plasma concentrations and degree of sensory anesthesia after a peripheral nerve block is currently unknown. The aim of this study was to characterize this relation using population pharmacokinetic–pharmacodynamic modeling. […]
Read MoreAuthors: Lacroix J et al., N Engl J Med 2015 Mar 17; The use of fresh red cells did not improve 90-day mortality for intensive-care patients. Red blood cells are stored for as long as 42 days prior to transfusion. Because prolonged storage induces red cell deterioration, the freshest units are often selected for transfusion of critically ill […]
Read MoreThis is important because we are often asked to intubate these patients. Authors: Badhiwala JH et al., Ann Intern Med 2015 Mar 17; 162:429 A systematic review found no significant missed injuries in obtunded blunt trauma patients who had normal CT imaging of their cervical spines. Given the significant morbidity and mortality associated with missed traumatic cervical […]
Read MoreAuthors: Capp R et al., Crit Care Med 2015 Jan 30; Nonpersistent hypotension and lactate level ≥4.0 mmol/L were the strongest predictors of progression to septic shock 4 to 48 hours after presentation. Among patients with sepsis, only a few progress to severe sepsis or septic shock. In these patients, however, early and aggressive treatment improves outcomes. […]
Read MorePublished in Anesthesiology Newly Published on 3 2015 Authors: Glenn S. Murphy, M.D. et al Background: The intensity of pain after cardiac surgery is often underestimated, and inadequate pain control may be associated with poorer quality of recovery. The aim of this investigation was to examine the effect of intraoperative methadone on postoperative analgesic requirements, pain scores, […]
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