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Uncategorized Published - 29 April, 2015    By - Dr Clemens
Comparison of vestipitant with ondansetron for the treatment of breakthrough postoperative nausea and vomiting after failed prophylaxis with ondansetron

Published in Br J Anaesth. 2015 Mar;114(3):423-9 Authors: Kranke P et al BACKGROUND: Postoperative nausea and vomiting (PONV) is common; ondansetron is often used as prophylaxis or for breakthrough episodes. Vestipitant is a neurokinin 1 (NK-1) receptor antagonist that is effective for prophylaxis, but its efficacy for treating established PONV is unknown. This study was […]

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Uncategorized Published - 29 April, 2015    By - Dr Clemens
Effect of combining tramadol and morphine in adult surgical patients: a systematic review and meta-analysis of randomized trials

Published in Br J Anaesth. 2015 Mar;114(3):384-95 Authors: Martinez V et al The role for tramadol in multimodal postsurgical analgesic strategies remains unclear. We undertook a systematic review to evaluate the utility of combining tramadol with morphine after surgery. We searched the MEDLINE, EMBASE, LILAC, Cochrane, and Clinical Trial Register databases for randomized, controlled studies […]

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Uncategorized Published - 28 April, 2015    By - Dr Clemens
Single-dose systemic acetaminophen to prevent postoperative pain: a meta-analysis of randomized controlled trials

Published in Clin J Pain. 2015 Jan;31(1):86-93 Authors: De Oliveira GS Jr et al OBJECTIVES: The effect of a single-dose systemic acetaminophen to treat postoperative pain has been previously quantified, but the effect of systemic acetaminophen to prevent postoperative pain is currently not well defined. The preventive analgesic effect of acetaminophen has yet to be […]

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Uncategorized Published - 28 April, 2015    By - Dr Clemens
Postoperative pain after laparoscopic cholecystectomy is not reduced by intraoperative analgesia guided by analgesia nociception index (ANI®) monitoring: a randomized clinical trial

Published in Br J Anaesth. 2015 Apr;114(4):640-5 Authors: Szental JA et al BACKGROUND: Laparoscopic cholecystectomy frequently results in significant immediate postoperative pain. A new pain monitor, analgesic nociception index (ANI(®)), based on heart rate variability, has recently been approved for intraoperative nociception monitoring. We designed a single-blind, parallel-group, randomized control trial to test the hypothesis […]

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Uncategorized Published - 28 April, 2015    By - Dr Clemens
Effects of different remifentanil target concentrations on MAC BAR of sevoflurane in gynaecological patients with CO2 pneumoperitoneum stimulus

Published in Br J Anaesth. 2015 Apr;114(4):634-9 Authors: Zou ZY et al BACKGROUND: To investigate the effects of different target plasma remifentanil concentrations on the minimum alveolar concentration of sevoflurane (MAC) for blocking adrenergic response (BAR) during laparoscopic gynaecological surgery with carbon dioxide insufflation. METHODS: Seventy-five gynaecological patients with ASA I-II undergoing laparoscopic surgery were […]

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