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Uncategorized Published - 13 July, 2015    By - Dr Clemens
The Relationship of Body Mass Index with the Incidence of Postdural Puncture Headache in Parturients

Published in Anesthesia & Analgesia: May 2015 Authors: Peralta, Feyce MD et al BACKGROUND: Unintentional dural puncture is a known risk after epidural or combined spinal-epidural procedures, occurring in approximately 1% of labor epidural catheters placed in parturients with normal body habitus but may be as high as 4% in morbidly obese parturients. Anecdotal experience […]

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Uncategorized Published - 13 July, 2015    By - Dr Clemens
The RECITE Study: A Canadian Prospective, Multicenter Study of the Incidence and Severity of Residual Neuromuscular Blockade

Published in Anesthesia & Analgesia: April 2015 Authors: Fortier, Louis-Philippe MSc, MD, FRCPC et BACKGROUND: Postoperative residual neuromuscular blockade (NMB), defined as a train-of-four (TOF) ratio of <0.9, is an established risk factor for critical postoperative respiratory events and increased morbidity. At present, little is known about the occurrence of residual NMB in Canada. The […]

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Uncategorized Published - 13 July, 2015    By - Dr Clemens
Topical Gel Promising in Migraine

A fast-acting transdermal gel using a proprietary formulation of the nonsteroidal anti-inflammatory drug (NSAID) ketoprofen (Topofen, Achelios Therapeutics) reduced pain severity in patients with severe migraine with and without aura compared with placebo and had few adverse effects. Results from a phase 2a trial of the gel were presented here at the American Academy of […]

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Uncategorized Published - 10 July, 2015    By - Dr Clemens
Predictors of Delayed Postoperative Respiratory Depression Assessed from Naloxone Administration

Published in Anesthesia & Analgesia May 2015 Authors: Weingarten, Toby N. MD et al BACKGROUND: The aim of this study was to identify patient and procedural characteristics associated with postoperative respiratory depression or sedation requiring naloxone intervention. METHODS: We identified patients who received naloxone to reverse opioid-induced respiratory depression or sedation within 48 hours after […]

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Uncategorized Published - 10 July, 2015    By - Dr Clemens
A Comparison of Differences Between the Systemic Pharmacokinetics of Levobupivacaine and Ropivacaine During Continuous Epidural Infusion: A Prospective, Randomized, Multicenter, Double-Blind Controlled Trial

Anesthesia & Analgesia: May 2015 Authors: Perotti, Luciano MD et al BACKGROUND: Epidural infusion of levobupivacaine and ropivacaine provides adequate postoperative pain management by minimizing side effects related to IV opioids and improving patient outcome. The safety profile of different drugs can be better estimated by comparing their pharmacokinetic profiles than by considering their objective […]

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