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Uncategorized Published - 16 July, 2015    By - Dr Clemens
Combined saphenous and sciatic catheters for analgesia after major ankle surgery: a double-blinded randomized controlled trial

Can J Anaesth. 2015 Aug;62(8):875-882 Authors: Fisker AK et al PURPOSE: Continuous sciatic nerve block is used for pain management following major ankle surgery. Pain from the saphenous nerve territory often persists. We conducted a double-blinded randomized placebo-controlled trial to evaluate the effect of a supplementary saphenous catheter in the proximal thigh combined with a popliteal sciatic […]

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Uncategorized Published - 16 July, 2015    By - Dr Clemens
A naloxone admixture to prevent opioid-induced pruritus in children: a randomized controlled trial

Can J Anaesth 2015 Aug;62(8):891-900 Authors: West N et al PURPOSE: Morphine administered by continuous opioid infusion (COI) or by patient-controlled analgesia (PCA) is associated with opioid-induced pruritus (OIP). Intravenous naloxone administered separately to the morphine infusion at a dose of 0.25-1.65 μg·kg-1·hr-1 can provide effective prevention from OIP. Nevertheless, this strategy requires a dedicated intravenous line and […]

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Uncategorized Published - 16 July, 2015    By - Dr Clemens
Efficacy of dexmedetomidine on postoperative shivering: a meta-analysis of clinical trials.

Can J Anaesth. 2015 Jul;62(7):816-829 Authors: Liu ZX et al PURPOSE: Shivering is a frequent complication in the postoperative period. The aim of the current meta-analysis was to assess the efficacy of dexmedetomidine on postoperative shivering. METHODS: Two researchers independently searched PubMed, EMBASE™ and the Cochrane Central Register of Controlled Trials for controlled clinical trials. The meta-analysis […]

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Uncategorized Published - 15 July, 2015    By - Dr Clemens
Rates of opioid dispensing and overdose after introduction of abuse-deterrent extended-release oxycodone and withdrawal of propoxyphene.

JAMA Intern Med. 2015 Jun;175(6):978-87 Authors: Larochelle MR et al IMPORTANCE: In the second half of 2010, abuse-deterrent extended-release oxycodone hydrochloride (OxyContin; Purdue Pharma) was introduced and propoxyphene was withdrawn from the US market. The effect of these pharmaceutical market changes on opioid dispensing and overdose rates is unknown. OBJECTIVE: To evaluate the association between 2 temporally […]

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Uncategorized Published - 15 July, 2015    By - Dr Clemens
Patient-controlled analgesia at the end of life at a pediatric oncology institution.

Pediatr Blood Cancer. 2015 Jul;62(7):1237-44 Authors: Anghelescu DL et al BACKGROUND: Patient controlled anesthesia (PCA) is increasingly used to manage pain in pediatric cancer patients and is important in the treatment of escalating pain at the end of life. The description of the use of opioid PCA in this population has been limited. PROCEDURE: This retrospective […]

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