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Use of clinician-recommended prescription opioids before the end of high school is associated with later opioid misuse — particularly among those high-schoolers who seem least likely to misuse drugs — a Pediatrics study finds. Researchers studied a nationally representative sample of 6200 youth who, in grade 12, completed questionnaires about drug use and then were followed up […]
Read MoreAm J Emerg Med 2015 Sep;33(9):1205-8. Authors: Fathi M et al OBJECTIVES: This randomized clinical trial compares the efficacy and safety of oral oxycodone (an oral opioid) with naproxen (a nonsteroidal anti-inflammatory drug) in acute pain control in patients with soft tissue injury. It also evaluates the need for additional doses of analgesics in the first 24 […]
Read MoreTwo analyses of the safety and efficacy of serotonin (5-HT3) receptor antagonists suggest that the most effective therapies for perioperative vomiting are ondansetron plus droperidol IV and granisetron plus dexamethasone (BMC Med 2015;13:136 and 142). Granisetron plus dexamethasone was also found to be one of the most effective therapies for nausea and for postoperative nausea and […]
Read MoreDose–Response Relationship in Cardiac Surgery: Ottawa, Ontario, Canada—Cardiac anesthesiologists can add acute kidney injury (AKI) to the many deleterious effects of intraoperative hypotension. A retrospective cohort study by a team of Canadian investigators found a relationship between kidney injury and mean arterial pressure (MAP) less than 65 mm Hg, but also uncovered evidence of a […]
Read MoreThe longer a patient is in severe pain during the first 24 hours following surgery, the more likely he or she will still be experiencing some form of chronic postsurgical pain one year later, according to a study presented at Euroanaesthesia 2015. This prospective, observational study (abstract ESAPC1-2), designed to investigate the incidence, characteristics and […]
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