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Uncategorized Published - 19 November, 2015    By - Dr Clemens
Adding Anticholinergic Therapy to Inhaled Corticosteroids in Black Patients

Authors: Wechsler ME et al., JAMA 2015 Oct 27; 314:1720 Tiotropium is not inferior to long-acting β-agonists for add-on asthma therapy. National asthma guidelines recommend long-acting β-agonists (LABAs) for patients whose asthma is not controlled by low-dose inhaled corticosteroids (ICS; J Allergy Clin Immunol 2007; 120:5 Suppl:S94); however, LABAs might be associated with risk for severe asthma exacerbations. […]

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Uncategorized Published - 19 November, 2015    By - Dr Clemens
Recombinant von Willebrand Factor for von Willebrand Disease

Authors: Gill JC et al., Blood 2015 Oct 22; 126:2038 Outcomes were excellent in 96.9% of bleeds in patients with severe disease. Patients with severe von Willebrand disease (VWD) have persistent, recurrent episodes of mucosal bleeding, menorrhagia, and bleeding with surgery or trauma. Treatment with plasma-derived von Willebrand factor (VWF) concentrates controls bleeding but exposes patients to […]

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Uncategorized Published - 19 November, 2015    By - Dr Clemens
Digital Palpation of the Cricothyroid Membrane Is Unreliable in Obese Laboring Patients

Authors: You-Ten KE et al., Anaesthesia 2015 Nov 70:1230 In laboring at-term patients, palpation of the cricothyroid membrane was less accurate in obese than in nonobese patients, whereas ultrasound identified the cricothyroid membrane in all patients. Obesity is a common marker of airway difficulty and may make a “can’t intubate, can’t oxygenate” scenario (and the need for […]

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Uncategorized Published - 18 November, 2015    By - Dr Clemens
Minor Postoperative Increases of Creatinine Are Associated with Higher Mortality and Longer Hospital Length of Stay in Surgical Patients

Authors: Felix Kork, MD et al Anesthesiology 12 2015, Vol.123, 1301-1311 Background: Surgical patients frequently experience postoperative increases in creatinine levels. The authors hypothesized that even small increases in postoperative creatinine levels are associated with adverse outcomes. Methods: The authors examined the association of postoperative changes from preoperative baseline creatinine with all-cause in-hospital mortality and hospital length of […]

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Uncategorized Published - 18 November, 2015    By - Dr Clemens
Oral Midodrine Hydrochloride for Prevention of Orthostatic Hypotension during Early Mobilization after Hip Arthroplasty: A Randomized, Double-blind, Placebo-controlled Trial

Authors: Oivind Jans, MD. PhD et al Anesthesiology 12 2015, Vol.123, 1292-1300 Background: Early postoperative mobilization is essential for rapid recovery but may be impaired by orthostatic intolerance (OI) and orthostatic hypotension (OH), which are highly prevalent after major surgery. Pathogenic mechanisms include an insufficient postoperative vasopressor response. The oral α-1 agonist midodrine hydrochloride increases vascular resistance, […]

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