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Uncategorized Published - 14 September, 2016    By - Dr Clemens
Electronically Mediated Time-out Initiative to Reduce the Incidence of Wrong Surgery: An Interventional Observational Study

Authors: Brian S. Rothman, M.D. et al  Anesthesiology 9 2016, Vol.125, 484-494 Background: “Wrong surgery” is defined as wrong site, wrong operation, or wrong patient, with estimated incidence up to 1 per 5,000 cases. Responding to national attention on wrong surgery, our objective was to create a care redesign intervention to minimize the rate of wrong surgery. […]

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Uncategorized Published - 14 September, 2016    By - Dr Clemens
Duloxetine and Subacute Pain after Knee Arthroplasty when Added to a Multimodal Analgesic Regimen: A Randomized, Placebo-controlled, Triple-blinded Trial

Authors: Jacques T. YaDeau, M.D., Ph.D. et al Anesthesiology 9 2016, Vol.125, 561-572 Background: Duloxetine is effective for chronic musculoskeletal and neuropathic pain, but there are insufficient data to recommend the use of antidepressants for postoperative pain. The authors hypothesized that administration of duloxetine for 15 days would reduce pain with ambulation at 2 weeks after total […]

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Uncategorized Published - 14 September, 2016    By - Dr Clemens
Low-dose Dexmedetomidine Improves Sleep Quality Pattern in Elderly Patients after Noncardiac Surgery in the Intensive Care Unit: A Pilot Randomized Controlled Trial

Authors: Xin-Hai Wu, M.D. et al Anesthesiology published on September 1, 2016 Background: Patients admitted to the intensive care unit (ICU) after surgery often develop sleep disturbances. The authors tested the hypothesis that low-dose dexmedetomidine infusion could improve sleep architecture in nonmechanically ventilated elderly patients in the ICU after surgery. Methods: This was a pilot, randomized controlled trial. […]

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Uncategorized Published - 14 September, 2016    By - Dr Clemens
STR-324, a Stable Analog of Opiorphin, Causes Analgesia in Postoperative Pain by Activating Endogenous Opioid Receptor–dependent Pathways

Authors: Philippe Sitbon, M.D. et al   Anesthesiology published on September 1, 2016 Background: Opiorphin is a naturally occurring potent analgesic human peptide. It protects enkephalins from degradation and inhibits pain perception in various acute pain models via activation of endogenous opioid pathways. However, the efficacy of opiorphin continuous infusion and its chemically stable form, STR-324, in postoperative […]

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Uncategorized Published - 13 September, 2016    By - Dr Clemens
Combined Spinal Epidural Technique for Labor Analgesia Does Not Delay Recognition of Epidural Catheter Failures: A Single-center Retrospective Cohort Survival Analysis

Authors: Jessica M. Booth, M.D. et al Anesthesiology 9 2016, Vol.125, 516-524. Background: It is unclear whether recognition of epidural catheter failures is delayed with combined spinal epidural technique (CSE) compared to traditional epidural technique (EPID) when used for labor analgesia. The authors hypothesized that recognition of failed catheters is not delayed by CSE. Methods: Anesthetic, obstetric, and […]

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