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Authors: Derek R. Laver, Ph.D. et al Anesthesiology 3 2017, Vol.126, 495-506. Background: Halogenated anesthetics activate cardiac ryanodine receptor 2–mediated sarcoplasmic reticulum Ca2+ release, leading to sarcoplasmic reticulum Ca2+ depletion, reduced cardiac function, and providing cell protection against ischemia-reperfusion injury. Anesthetic activation of ryanodine receptor 2 is poorly defined, leaving aspects of the protective mechanism uncertain. Methods: Ryanodine receptor 2 […]
Read MoreThe lack of pain specialists in many parts of the US has almost reached a crisis point, making the question of when and why to refer a patient especially timely. The recent Centers for Disease Control and Prevention (CDC) guidelines for opioid management suggest that clinicans should increase the frequency of follow-up visits when prescribing […]
Read MoreWhile well known as a significant factor in overall health, vitamin D deficiency could influence the occurrence of frequent headaches, especially in patients underexposed to sunlight. Given that dietary vitamin D has been identified in the development of various neurovascular diseases, such as neurocognitive decline and ischemic stroke,1,2 it was a matter of time before vitamin […]
Read MoreNew epidemiological evidence suggests that patients at greater risk of opioid abuse and misuse could be the same patients who are more likely to receive prescriptions for pain for an extended period of time. Interview with Patrick D. Quinn, PhD, and Robert J. Gatchel, PhD, ABPP With a rising rate of opioid prescribing among patients […]
Read MoreMany people regularly take nonprescription pain relievers to manage or treat minor aches and pains. Yet some of these medications, when used regularly for an extended period of time, may increase the risk of hearing loss. Interview with Brian M, Lin, MD Today, approximately 48 million Americans suffer from some form of hearing loss, and […]
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