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Anesthesiology Published - 9 January, 2026    By - Dr Clemens
Critical Closing and Tissue Perfusion Pressures in Sepsis—Implications for Risk Stratification

Authors: Wang J-Y et al. Journal: Anesthesiology, December 5, 2025. DOI: 10.1097/ALN.0000000000005881 SummaryThis large retrospective cohort study evaluated whether critical closing pressure (Pcc) and tissue perfusion pressure (TPP) improve prognostication and risk stratification in patients with sepsis beyond mean arterial pressure (MAP) alone. While MAP is the cornerstone hemodynamic target in sepsis management, it does […]

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Anesthesiology Published - 9 January, 2026    By - Dr Clemens
Association between Multisite and Site-specific Chronic Pain, Analgesic Use, Metabolic–Proteomic Profile, and Incident Chronic Kidney Disease in Diabetes

Authors: Yang S et al. Journal: Anesthesiology, December 9, 2025. DOI: 10.1097/ALN.0000000000005829 SummaryThis large prospective cohort study examined the relationship between chronic pain patterns, analgesic use, and the development of chronic kidney disease (CKD) in individuals with diabetes, while also exploring associated metabolic and proteomic signatures. Given the high prevalence of chronic pain in diabetes […]

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Anesthesiology Published - 9 January, 2026    By - Dr Clemens
How 1 anesthesia leader plans to tackle workforce shortages in 2026

Author: Francesca Mathewes Becker’s ASC Review Leaders in anesthesia, especially those in the outpatient setting, are juggling numerous challenges amid workforce shortages, declining reimbursements and costly inefficiencies. Jeff Tieder, MSN, CRNA, a clinical assistant professor at the University of Tennessee at Chattanooga recently joined Becker’s to discuss his plans for combating the industry’s various challenges in 2026. Editor’s note: This […]

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Anesthesiology Published - 9 January, 2026    By - Dr Clemens
Single Muscle Fibre Calcium Wave Frequency Assay for Malignant Hyperthermia Diagnosis

Authors: Singh DP et al. Journal: Anesthesiology, December 5, 2025. DOI: 10.1097/ALN.0000000000005882 SummaryThis exploratory validation study evaluated a novel diagnostic approach for malignant hyperthermia (MH) susceptibility using a single muscle fiber calcium wave frequency assay (CaWFa). Given the limitations of the current gold standard in-vitro contracture test (IVCT), including invasiveness, tissue requirements, and indirect measurement […]

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Anesthesiology Published - 9 January, 2026    By - Dr Clemens
Modulation of pain sensitivity by the locus coeruleus–paraventricular thalamic nucleus–anterior cingulate cortex pathway in mice

Authors: Kuai S et al. Journal: Anesthesiology, December 11, 2025. DOI: 10.1097/ALN.0000000000005897 SummaryThis preclinical neurocircuitry study investigated how noradrenergic signaling from the locus coeruleus (LC) modulates pain sensitivity through distinct downstream pathways involving the paraventricular thalamic nucleus (PVA) and the anterior cingulate cortex (ACC). Although LC projections to both the thalamus and cortex are known […]

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