Author: Dr Clemens

Anesthesiology Published - 9 January, 2026    By - Dr Clemens
Modulation of pain sensitivity by the locus coeruleus–paraventricular thalamic nucleus–anterior cingulate cortex pathway in mice

Authors: Kuai S et al. Journal: Anesthesiology, December 11, 2025. DOI: 10.1097/ALN.0000000000005897 SummaryThis preclinical neurocircuitry study investigated how noradrenergic signaling from the locus coeruleus (LC) modulates pain sensitivity through distinct downstream pathways involving the paraventricular thalamic nucleus (PVA) and the anterior cingulate cortex (ACC). Although LC projections to both the thalamus and cortex are known […]

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Anesthesiology Published - 8 January, 2026    By - Dr Clemens
Sex-specific Effects of Acute Stress on Emergence from Isoflurane Anesthesia via Brainstem Circuitry in Mice

Authors: Zhao X et al. Journal: Anesthesiology, December 9, 2025. DOI: 10.1097/ALN.0000000000005826 SummaryThis preclinical mechanistic study investigated how acute stress alters anesthetic efficacy and emergence from isoflurane anesthesia, with a focus on sex-specific effects and underlying brainstem circuitry. Recognizing that preoperative stress contributes to variability in anesthetic depth and recovery, the authors aimed to define […]

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Anesthesiology Published - 8 January, 2026    By - Dr Clemens
Pain management’s evolving place in spine care

Author: Carly Behm Becker’s Spine Review In spine care, surgeons and nonsurgical pain management physicians have had some tensions over who addresses different procedures, especially as minimally invasive procedures become more widespread. However, interspecialty collaboration is becoming a bigger priority. William Mitchell, MD, president of the North American Spine Society, said this will be a […]

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Anesthesiology Published - 8 January, 2026    By - Dr Clemens
Suzetrigine for the Treatment of Acute Pain: Reply

Authors: Bertoch T et al. Journal: Anesthesiology, December 11, 2025. DOI: 10.1097/ALN.0000000000005825 SummaryThis reply addresses multiple commentaries regarding the clinical meaningfulness, demographic consistency, and comparative efficacy of suzetrigine for moderate-to-severe acute pain. The authors clarify points raised about subgroup effects, outcome interpretation, and comparison with established opioid analgesics. The authors emphasize that phase 3 randomized […]

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Anesthesiology Published - 8 January, 2026    By - Dr Clemens
Relationship between Ventilation/Perfusion Ratio Mismatch and Capnogram Phase III Slope in Acute Bronchoconstriction and Its Modulation by Salbutamol Assessed by Synchrotron Imaging in Rabbit Lung

Authors: Bayat S et al. Journal: Anesthesiology, December 12, 2025. DOI: 10.1097/ALN.0000000000005807 SummaryThis experimental physiologic study examined whether the slope of phase III of the volumetric capnogram (SIII) truly reflects ventilation–perfusion (V/Q) mismatch during acute bronchoconstriction and how this relationship is altered by bronchodilator therapy. Using a rabbit model and high-resolution synchrotron radiation imaging, the […]

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Anesthesiology Published - 8 January, 2026    By - Dr Clemens
BEST Independent CRNA Opportunity – Savannah, TN just increased salary $15,000

Hardin Medical Center (122 beds) is offering a rare CRNA-only practice where you can enjoy full autonomy and an exceptional lifestyle. • Schedule: 2 weeks on / 1 week off (17 weeks off each year)• Model: Independent CRNA practice – no anesthesiologist supervision• Case Mix: General surgery, orthopedics, endoscopy, OB/GYN (including epidurals & C-sections)• No […]

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Anesthesiology Published - 8 January, 2026    By - Dr Clemens
Suzetrigine for the Treatment of Acute Pain: Comment

Authors: Siddiqui A et al. Journal: Anesthesiology, February 2026 (accepted October 17, 2025). DOI: 10.1097/ALN.0000000000005828 SummaryThis letter to the editor provides a critical appraisal of recently published phase 3 trials evaluating suzetrigine for the treatment of moderate-to-severe acute pain. The authors focus on the interpretation of efficacy metrics and whether the reported outcomes meet accepted […]

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Anesthesiology Published - 7 January, 2026    By - Dr Clemens
Intraoperative Cardiac Events in Pediatric Patients with Congenital Heart Disease Undergoing Noncardiac Procedures

Authors: Nasr VG et al. Journal: Anesthesiology, December 9, 2025. DOI: 10.1097/ALN.0000000000005783 SummaryThis large multicenter registry study evaluated the incidence and risk factors for intraoperative cardiac events in pediatric patients with congenital heart disease (CHD) undergoing noncardiac procedures. Unlike prior studies limited to mortality outcomes or single-center experiences, this analysis provides granular, contemporary data on […]

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Anesthesiology Published - 7 January, 2026    By - Dr Clemens
Respiratory and antinociceptive effects of NOP-MOP agonist cebranopadol versus full opioid receptor agonist oxycodone

Authors: Jansen S et al. Journal: Anesthesiology, December 11, 2025. DOI: 10.1097/ALN.0000000000005894 SummaryThis randomized, double-blind, placebo-controlled crossover study compared the respiratory and analgesic effects of cebranopadol—a dual nociceptin (NOP) and mu-opioid (MOP) receptor agonist—with those of the full MOP agonist oxycodone in healthy volunteers. Given ongoing concerns about opioid-induced respiratory depression, the investigators sought to […]

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Anesthesiology Published - 7 January, 2026    By - Dr Clemens
The 5 biggest anesthesia disruptions coming in 2026

Author: Sophie Eydis Becker’s ASC Review Anesthesiology is heading into a pivotal year, as workforce volatility, reimbursement pressure and policy shifts collide with rising surgical demand and expanding outpatient care. After a period of partial stabilization, leaders say the structural forces reshaping how anesthesia is staffed, paid and deployed are intensifying, with direct implications for hospitals, […]

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