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Authors: Jacqueline M. Leung, M.D., M.P.H. et al Anesthesiology October 2023, Vol. 139, 432–443. Background The pathophysiology of delirium is incompletely understood, including what molecular pathways are involved in brain vulnerability to delirium. This study examined whether preoperative plasma neurodegeneration markers were elevated in patients who subsequently developed postoperative delirium through a retrospective case-control study. Methods […]
Read MoreAuthors: Edita Navratilova, Ph.D. et al Anesthesiology September 2023. Background The efficiency of descending pain modulation, commonly assessed with the conditioned pain modulation (CPM) procedure, is diminished in patients with chronic pain. We hypothesized that the efficiency of pain modulation is controlled by cortical opioid circuits. Methods We evaluated the effects of mu opioid receptor […]
Read MoreAuthor: Wael Saasouh, MD IARS Newsletter Issue 4 Intraoperative hypotension has been shown to negatively influence patient outcomes based on large trials from major academic centers. During the session, “A Pragmatic Discussion on Intraoperative Hypotension” on Saturday, April 15 at the IARS 2023 Annual Meeting, experts on this topic shared the results of similar work […]
Read MoreAUTHORS: Barsky, Daniel MD et al Anesthesia & Analgesia 136(5):p 934-940, May 2023. BACKGROUND: Hemorrhage is the leading cause of preventable death in trauma patients, and establishment of intravenous (IV) access is essential for volume resuscitation, a key component in the treatment of hemorrhagic shock. IV access among patients in shock is generally considered more challenging, […]
Read MoreAUTHORS: Martinez, Thibault MD et al Anesthesia & Analgesia 136(5):p 842-851, May 2023. BACKGROUND: Traumatic rhabdomyolysis (RM) is common and contributes to the development of medical complications, of which acute renal failure is the best described. Some authors have described an association between elevated aminotransferases and RM, suggesting the possibility of associated liver damage. Our study […]
Read MoreAUTHORS: Muldowney, Maeve MB, BCh, BAO et al Anesthesia & Analgesia 136(5):p 927-933, May 2023. BACKGROUND: Uncontrolled bleeding is a leading cause of death in trauma. In the last 40 years, ultramassive transfusion (UMT; ≥20 units of red blood cells [RBCs]/24 hours) for trauma has been associated with 50% to 80% mortality; the question remains as […]
Read MoreAUTHORS: Barajas, Matthew B. MD et al Anesthesia & Analgesia 136(5):p 941-948, May 2023. BACKGROUND: Early detection and quantification of perioperative hemorrhage remains challenging. Peripheral intravenous waveform analysis (PIVA) is a novel method that uses a standard intravenous catheter to detect interval hemorrhage. We hypothesize that subclinical blood loss of 2% of the estimated blood volume […]
Read MoreAUTHORS: Keneally, Ryan J. MD et al Anesthesia & Analgesia 136(5):p 920-926, May 2023. BACKGROUND: Warm, fresh whole blood (WB) has been used by the US military to treat casualties in Iraq and Afghanistan. Based on data in that setting, cold-stored WB has been used to treat hemorrhagic shock and severe bleeding in civilian trauma patients […]
Read MoreAUTHORS: Bandyopadhyay, Anjishnujit DM et al Anesthesia & Analgesia 136(5):p 913-919, May 2023. BACKGROUND: Critically injured patients who are agitated and delirious on arrival do not allow optimal preoxygenation in the emergency area. We investigated whether the administration of intravenous (IV) ketamine 3 minutes before administration of a muscle relaxant is associated with better oxygen saturation […]
Read MoreAUTHORS: Barclay-Steuart, Alexander MD, MBA et al Anesthesia & Analgesia 136(6):p 1164-1173, June 2023. | BACKGROUND: Transnasal flexible videoendoscopy (TVE) of the larynx is a standard of care for the detection and staging of pharyngolaryngeal lesions in otorhinolaryngology. Patients frequently present with existing TVE examinations before anesthesia. Although these patients are considered high risk, the diagnostic value […]
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